Scientist at DKFZ and NCT Heidelberg
#epigenetics #stemcells #leukemia #colorectalcancer #multiomics #precisiononcology
#oncofetal #reprogramming
#plasticity
www.translational-cancer-epigenomics.de
Mark Hartmann
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Editors’ Pick by Cancer Research Catalyst @aacrjournals.bsky.social
RAS-driven plasticity and oncofetal reprogramming as a key mechanism and vulnerability in JMML.
The article is freely available for a limited time:
www.aacr.org/blog/2026/03...
#hematology
#oncology
#epigenetics
#development
Same mutation ≠ same leukemia.
Wagenblast et al. show:
• fetal HSCs readily transform
• postnatal HSCs become resistant
• fetal programs create targetable vulnerabilities
Ontogeny matters: state-of-origin shapes biology & therapy response.
doi.org/10.1158/2159...
#pediatric #AML #stemcells
New Spotlight in @aacrjournals.bsky.social
#Oncogene × #Ontogeny × #Plasticity shape leukemia biology & therapy response.
Two complementary studies show: mutations alone don’t explain disease behavior—developmental state and cellular plasticity matter.
aacrjournals.org/bloodcancerd...
🩸🧬
EpiSci
Looking forward to a great scientific program with @bethpsaila.bsky.social, Simón Méndez-Ferrer, Jian Xu and many more exciting short talks.
Join us on April 16 to discuss developmental programs in leukemia.
@isehsociety.bsky.social
JMML stem cells aren’t epigenetically “stuck” in a fetal state.
They mature postnatally—yet show striking transcriptional plasticity, with oncofetal reprogramming in high-risk disease, challenging the classic “maturation block” model.
doi.org/10.1158/2643...
#JMML #epigenetics #hematology #cancer
Out in print this week @bloodjournal.bsky.social . Very proud of this collaborative work with Prof Karadimitris @imperialimmuno.bsky.social. Thanks to @cancerresearchuk.org and CwC_UK for funding this work. #InfantALL @paediatrics.ox.ac.uk @imm.ox.ac.uk
Excited to present our work at the 2026 #ISEH Mini Symposium!
“Beyond the Maturation Block: Oncofetal Reprogramming and Stem Cell Plasticity in Pediatric Leukemia”
Join us on April 16 to discuss developmental programs in leukemia and beyond.
iseh.org/Webinars-Eve...
Thanks for sharing our study!
#Kinderkrebs
#Leukämie
@dkfz.bsky.social
@nct-heidelberg.bsky.social
Very pleased to share our latest pre-print which showcases the incredible hard work and skill of Dr Okan Sevim.
Our continued exploration of β-catenin's contribution to the post transcriptional landscape of blood cells led us to a LIN28B interaction.
1/7
www.biorxiv.org/content/10.6...
🚨We have an opening for Data Scientists or Bioinformaticians using machine learning and AI with all kinds of molecular data to support cancer research. 🧬
Permanent position, fantastic team, exciting projects—what more could you ask for?
www.lih.lu/en/job/?valu...
Andi Roy
www.aacr.org
In March, AACR's journals editors highlighted studies on the development of pediatric leukemia, the use of low-dose tamoxifen, and more.
