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PHOENIX — Screening healthy patients for glaucoma during routine eye exams led to glaucoma referrals that would not have been made otherwise, according to a prospective study presented at Optometry’s Meeting. Out of 104 patients, 13 were referred for further glaucoma evaluation, and one was diagnosed with active disease. The study was presented by Michael Chaglasian, OD, FAAO, of Illinois College of Optometry. During routine eye exams at Illinois Eye Institute, 104 patients aged 35 years or older were offered free spectral-domain OCT imaging using Maestro2 (Topcon Healthcare). The average age of

DENVER — A real-world analysis showed increased rates of undertreatment and attrition with anti-VEGF injections in patients with wet age-related macular degeneration over time, resulting in worse visual outcomes. According to a poster presented at the Association for Research in Vision and Ophthalmology meeting, the study aimed to address the knowledge gaps on the long-term impact of nonpersistence in anti-VEGF treatment on visual outcomes. “We performed a retrospective analysis of the Vestrum Health database to characterize the impact of a 6-month treatment gap in new wet AMD patients

Aims To characterise the clinical and morphological features of ocular surface toxicity induced by human epidermal growth factor receptor 2 (HER2)-targeted antibody–drug conjugates (ADCs) in patients with HER2-positive breast cancer, guiding clinical intervention.Methods 21 HER2-positive breast cancer patients receiving HER2-ADC therapy were enrolled. Assessments included best corrected visual acuity, the Ocular Surface Disease Index, conjunctival lissamine green staining, tear break-up time, tear meniscus height, Meibomian Gland Score, Strip Meniscometry Tube (SMTube strips), corneal sensitivity (Cochet-Bonnet esthesiometry), anterior segment optical coherence tomography and in vivo confocal microscopy (IVCM) to evaluate morphology, corneal nerve fibre density and length, and endothelial cell density. Transmission electron microscopy (TEM) was performed in selected cases. All parameters were compared from baseline to follow-up.Results Ocular surface toxicity occurred in 85.7% (18/21) of patients after HER2-ADC therapy, with a mean onset at 28.0±8.4 days. Vortex-like keratopathy progressed from inferior subepithelial microcysts to linear deposits and a vortex pattern. IVCM revealed severe subepithelial nerve fibre fragmentation and loss. TEM revealed epithelial extracellular matrix fibrosis, mitochondrial damage (swelling, disordered cristae, vacuolisation), nuclear alterations (chromatin dispersion, electron-dense deposits) and suspected endocytic vesicles. Lesions appeared dose- and time-dependent and showed partial reversibility. After 12 cycles, corneal structure and transparency showed restoration trends.Conclusion HER2-ADC-induced ocular surface toxicity presents as vision loss, dry eye and selective damage to corneal epithelium (vortex-like keratopathy) and nerves (nerve fibre loss and reduced sensitivity), which is dose- and time-dependent and partially reversible.

Every day, millions of people scroll through transformation videos on social media in pursuit of becoming the most attractive version of themselves. But for some young men, this goal has taken a dark turn. Combining the terms “looks” and “maximizing,” a movement called “looksmaxxing” teaches young men that the key to success is to radically improve their physical appearance through any means necessary, according to an NPR article. While “looksmaxxing” strategies such as working out or optimizing skin care routines are usually harmless, a trend popularized on social media called “bonesmashing,”