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Scientist working on antibiotic resistance, evolution, and mobile genetic elements. Prof at U.Oxford and Fellow of All Souls College
Craig MacLean
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This is our first paper of plasmid-dependent phage, with more papers coming soon. This project was a team effort, but I want to highlight the excellent work done by Daniel Cazares and Eliza Rayner.
7d
And the preprint is out! www.biorxiv.org/content/10.6... We compared plasmid conjugation in liquid and on solid across 13 AMR plasmids with different types of conjugative pili.
2mo
Craig MacLean
Final version of our last paper is out! www.nature.com/articles/s41...
Please share widely! Abstract submissions open for the 2026 Jacques Monod conference: Ecology and evolution of host-parasite interactions in a changing world! Held in beautiful Roscoff France from November 2- 6, 2026. Abstracts submission deadline : June 6 cjm.sb-roscoff.fr/en/conferenc...
22d
3mo
cjm.sb-roscoff.fr
Ecology and evolution of host-parasite interactions in a changing world | CNRS - Conférences Jacques Monod (CJM)
Inactivation of chromosomal genes through plasmid-encoded IS elements is an extended mechanism of antimicrobial resistance evolution in bacteria.
www.nature.com
Plasmid-dependent phage use the conjugative plus as a receptor to infect bacterial cells. As such, they may be an important tool to kill bacteria carrying plasmids #AMR plasmids and stop the spread of AMR plasmids between strains/species. In this paper we use experimental evolution...
Interestingly, the phage resistance mutations that we observed in our experiments are quite common in IncP plasmids, suggesting that plasmid-depedent phage may impose quite an important barrier to conjugative plasmid transfer!
Plasmids promote antimicrobial resistance through insertion sequence-mediated gene inactivation - Nature Microbiology
To study responses to the PRD1 phage in simple two strain communities with the RP4 plasmid. Under conditions where opportunities for conjugation are limited, the plasmid rapidly adapts to phage through loss of conjugative ability and the phage has a transient suppressive effect.
With greater opportunity for conjugation the phage supresses the plasmid more effectively. This is because of a complex trade-off between conjugative ability and phage resistance mediated by mutations in the conjugative apparatus.
I have been reading through papers on evolution and microbes from the 1940s to 1960s. I have found some amazing work, but I am sure that there is much more that I haven’t found. Can you send me links to classic evolution+microbiology papers from pre Levin era?
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2mo
Excited to share this new paper from the lab: academic.oup.com/ismej/articl...! See thread below
Tatiana Dimitriu
Craig MacLean
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Craig MacLean
Craig MacLean
Craig MacLean
Craig MacLean
Britt Koskella
Alvaro San Millan
academic.oup.com
Abstract. Phage therapy offers an alternative to antibiotics for treating multidrug-resistant infections. Plasmid-dependent phages (PDPs) are promising the
Eco-evolutionary responses to plasmid-dependent phage constrain the spread of multidrug-resistance plasmids
Craig MacLean