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International Open Access journal publishing on molecular and translational medicine. IF 2024,9.4; Scopus Citescore 2024, 8.4.

Genes & Diseases Journal

This review highlights how the m6A reader #YTHDF2 regulates immune signaling and RNA fate across #InflammatoryDiseases, uncovering new opportunities and challenges for epigenomic-based targeted therapies. #RNAepigenetics #OpenAccess: doi.org/10.1016/j.ge...

12h

Genes & Diseases Journal

Researchers identify CNTD1 as a novel cause of #DiminishedOvarianReserve (#DOR), showing that CNTD1 mutations disrupt #meiosis through loss of PRR19 interaction, leading to premature follicle depletion and impaired #FemaleFertility. #OpenAccess: doi.org/10.1016/j.ge...

This review highlights how single-cell and #SpatialOmics reveal cellular diversity, lineage dynamics, and regenerative signaling in #craniofacial tissues, advancing precision strategies for developmental disorders & future therapies. @pku1898.bsky.social Read: doi.org/10.1016/j.ge...

This review decodes #Megalin binding mechanisms driving protein reabsorption, coagulation, and #Neuroprotection, highlighting the therapeutic potential of #GeneEditing and monoclonal antibodies for renal, metabolic, and #neurodegenerative diseases. #OpenAccess: doi.org/10.1016/j.ge...

psiTPTE22-HERV, a human-specific gene, is silenced by promoter methylation in #GastricCancer; restoring its expression suppresses PI3K/AKT/mTOR signaling, limits #TumorGrowth and #metastasis, and low levels predict poor survival. #OpenAccess: doi.org/10.1016/j.ge...

Researchers identify TYW5 as a novel #Schizophrenia risk gene, showing that its dysregulation alters #CircadianClock networks, reshapes #prefrontal synaptic architecture, and drives behavioral changes linked to disease pathology. #OpenAccess: doi.org/10.1016/j.ge...

This review highlights how #RBM15-mediated #m6A methylation regulates #RNAstability and translation across #cancer and metabolic diseases, uncovering therapeutic potential through targeted therapies and RBM15-based gene interventions. #OpenAccess: doi.org/10.1016/j.ge...

📣 New: ESMO Advanced and Metastatic Prostate Cancer Living Guideline, with recommendations and algorithms from the 2026 CPG, in a mobile friendly interactive format. Prepared by K Fizazi and S Gillessen 🔗 https://ow.ly/7ini50Z9jG3 #ClinicalPracticeGuideline #ESMOGuidelines

16h

14h

Help shape the future of AI in precision medicine. Abstracts are open for ASHG’s Virtual Symposium, The Intelligent Genome: Powered by AI We’re seeking emerging research, case reports, and applied AI/ML innovations in genomics. Submit now and be part of the conversation. https://bit.ly/3QDNidF

Genes & Diseases Journal

ESMO - European Society for Medical Oncology

EPCORE DLBCL-1: #EHA2026: Epcoritamab outperformed investigator’s choice of CIT in relapsed/refractory large B-cell lymphoma, improving PFS and delivering durable complete responses. ✅ Higher CR rate ✅ More durable remissions ✅ 27% PFS at 3 years Read more: www.onclive.com/view/epcorit...

American Society of Human Genetics (ASHG)

OncLive

Epcoritamab improved PFS and produced durable complete responses vs chemoimmunotherapy in relapsed/refractory large B-cell lymphoma.

www.onclive.com

Epcoritamab Significantly Improves PFS Vs Chemoimmunotherapy in R/R Large B-Cell Lymphoma | OncLive