Germline genome regulation & genetic conflicts
piRNAs | paralogs | epigenetics | transposons | flies
Group leader, Aarhus University, Denmark (https://mbg.au.dk/pan)
YOLO but germ cells are immortal and I wanna know how they do that.
Peter Andersen
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A big preprint from my group!
Muller Elements are considered to be conserved in flies. We tested it by reconstructing the ancestral dipteran karyotype using 340 chromosomal genomes and suprise suprise, they're not...
Led by @juliagries.bsky.social and Sam Ebdon. www.biorxiv.org/content/10.6...
🧵👇
New preprint! In an fun collaboration with @imaeso.bsky.social and @mirimiam.bsky.social led by Manu F-M, we set to explore the potential adaptation of transposable elements 👾 to host adenine DNA methylation by recruiting prokaryotic DAM methyltransferases: www.biorxiv.org/content/10.6.... 1/6
www.biorxiv.org
Alex de Mendoza
KamilSJaron.bsky.social
Just one more week to apply to join us in December to discuss development from a Unicellular perspective!
Archaea are the hornets of the microbial world. Discuss.
www.biorxiv.org/content/10.6...
TLDR: Archaeon kills bacterium with secreted phospholipase. Pretty nifty way to kill bacteria for a microbe with a very different lipid make-up, I reckon. No need to worry about accidentally killing yourself.
www.biorxiv.org
Tobias Warnecke
This work nicely quantifies a major issue in our universities: "In higher education, administrative costs have risen much faster than instruction and research costs (4). MIT Faculty grew by only 9.2% between 1985 and 2023, while administrative staff grew by 189%." www.pnas.org/doi/10.1073/...
James Gahan
Doing a linear stretch on these images shows how dramatic the "edits" were, revealing the deception in clear terms.
This should be a complete scandal for Thermo Fisher and more people in the biosciences should be talking about it.
And some lizards are more closely related to snakes than they are to other lizards! Biology is weird.
Join our lab to study transcriptional regulation in mouse germ cells and embryonic stem cells at
@haskoliislands.bsky.social in beautiful Reykjavík!
Apply here: tinyurl.com/mryvhdwj
#epigenetics #TranscriptionFactors #transcriptomics #stemCells #pluripotency
Out now in Science! Our study challenges long-standing assumptions about transcription factor specificity in eukaryotes. Novel single-molecule measurements of TF behavior in living cells reveal an independence of locus-specific binding from DNA sequence recognition.🧵
www.science.org/doi/10.1126/...
Michael Hothorn
How intrinsically disordered regions (IDRs) shape chromatin binding and nuclear organization of transcription factors (TFs) remains unclear. We used proximity-assisted photoactivation (PAPA), a single...
The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes:
🖌️ Dozens more images with duplications or painting
🖨️ Hundreds of blots that all share the same background (behold slideshow below)
Erna Magnúsdóttir
Video
Reese Richardson
Rachel W. Martin
BWJones
Rethinking Cell Differentiation and Development: A Unicellular Perspective Workshop
@biologists.bsky.social is delighted to announce a new Workshop. Early-career researchers apply for funded places by 12 June 2026.
thenode.biologists.com/rethinking-c...
Dr. Arturo Marí-Ordónez, duckweed and Transposons. TEs get crazy in Wolffia! Please check his rescent preprint doi.org/10.64898/202...
@mangolab.bsky.social what do you think about this?
@psb-vib.bsky.social @gmivienna.bsky.social
Tjian + Darzacq Lab, UC Berkeley
We are delighted to announce the Workshop 'Rethinking Cell Differentiation and Development: A Unicellular Perspective'. Early-career researchers apply for funded places by 12 June 2026.
