Neuroimmunologist studying MS, autism, Alzheimer's disease, and brain injury at the University of Virginia. Father of two. Fan of Philly sports and US soccer.
www.lukenslab.com
John Lukens
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Gateways for myeloid cell entry into the central nervous system: Neuron www.cell.com/neuron/fullt...
Neuron-derived mitochondrial DNA (mtDNA) activates microglia via the Z-DNA binding protein 1 (ZBP1)-mediated pathway in mild traumatic brain injury
www.pnas.org/doi/abs/10.1...
Macrophage-mediated refinement of the dural lymphatic regulates social behavior: Neuron www.cell.com/neuron/fullt...
Somatic cancer variants enriched in Alzheimer’s disease microglia-like cells drive inflammatory and proliferative states: Cell www.cell.com/cell/fulltex...
Amyloid-β-driven glymphatic dysfunction in Alzheimer’s disease model mice is driven by Ca2+-mediated increases in astrocytic cholesterol
www.nature.com/articles/s41...
SARM1 executes neuronal parthanatos and promotes excitotoxic cell death
www.cell.com/neuron/fullt...
JCI - Western diet induces iron-dependent enteric neurodegeneration via ferroptosis www.jci.org/articles/vie...
Astrocytic calcium-dependent enzyme PAD2 governs microglia activity to exacerbate amyloid pathology via citrullinated vimentin @cp-immunity.bsky.social www.cell.com/immunity/ful...
UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration
www.nature.com/articles/s41...
Evolving brain-immunity: From Ramón y Cajal’s mysterious butterflies to a garden sustained by immune cells as their nectar: www.cell.com/neuron/fullt... 🦋💐 @cp-neuron.bsky.social
John Lukens
John Lukens
John Lukens
John Lukens
John Lukens
John Lukens
John Lukens
John Lukens
John Lukens
John Lukens
ALS/FTD-linked mutations in UBQLN2, a protein quality control factor, impair degradation of enzymes essential for mitochondrial lipid catabolism, leading to metabolic dysfunction and neurodegeneration...
Over the last three decades, dogma-breaking studies have refuted the brain’s assumed
immune isolation. Echoing Ramón y Cajal metaphor of neurons as “butterflies,” Schwartz
proposes viewing the brain a...
