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The concept of antagonisitic pleiotropy in aging (well established for senescence) revisited for the case of infectious diseases. 👇
4mo
Nicolas Manel Lab
How does ageing influence the way our bodies handle infection? go.nature.com/4sMZuqW
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In life-threatening sepsis, the same signalling pathway that protects young mice from succumbing to organ dysfunction exacerbates damage and lethality in older animals.
go.nature.com
Ageing rewires the body’s tolerance to infection
Nature