Featured: Drs. Du, Tang et al. found that SCFA-FFAR2 signaling reduces visceral hypersensitivity in both sexes, but only males rely on FFAR2-dependent suppression of IL-17RA signaling in the anterior cingulate cortex
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Sex differences in visceral hypersensitivity (VH) has been demonstrated, while the underlying mechanism needs to be elucidated. A sodium dextran sulfate (DSS)-induced acute colitis mouse model was…