First Preprint from my group @NIHIRP, where a summer project led by Vanshika Chaddha took unexpected turn into identifying Primary Cilia across the Brain Vasculature.
New avenues for NVC.
Amazing Collaboration with @sorengrubb.bsky.social, Carolyn Ott and Jennifer Lippincott-Schwartz.
Preprint alert: Check out our latest work 'Electro-Calcium Uncoupling in Capillary Endothelial Cells Precedes Neurodegeneration in Alzheimer's disease'. We used Young 5xFAD mice to decipher neurovascular communication deficits in pre-symptomatic phase of AD.
www.biorxiv.org/content/10.6...
Electro-Calcium uncoupling precedes neurodegeneration in Alzheimers disease https://www.biorxiv.org/content/10.64898/2026.01.26.701803v1
Thanks @sorengrubb.bsky.social for creating this 🧵 to summarize the findings. Thanks @alleninstitute.org @hhmijanelia.bsky.social and @helenelab.bsky.social for the EM datasets.
#EM #Cilia #brainvasculature
Excited to share our first pre-print from the new SSPB section at the NIDCD!🥳
We hope you find it interesting and inspiring for future research. Thanks to our team, colleagues, mentors and collaborators 🔥 💪 🙏 .
Take a look—and stay tuned for more!
www.biorxiv.org/content/10.1...
Amreen Mughal
Amreen Mughal
🐭🧠 #PrecapillarySphincters (PS) at the #arteriole–#capillary junction rapidly dilate ~30% in seconds during #SensoryStimulation—regulating #capillary #BloodFlow dynamically. Here we investigated whether they protect downstream microvessels during abrupt #BloodPressure surges 🧪🧵
bioRxiv Neuroscience
Join us in congratulating the CCAD Cohort of 2026! We look forward to their innovative contributions to the field of Alzheimer’s disease and the CCAD community.
#CCAD2026 #AlzheimersDisease #NewVisionResearch
Amreen Mughal
Posting for Vibhu Sahni:
Due to unforeseen circumstances the Burke Neurological Institute will have to terminate its research operations 5/22. There are international postdocs on visas who are looking for new homes. Please reach out to Vibhu if you can help
