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The official account of Nature Reviews Cardiology, a monthly journal publishing high-quality Reviews, news and opinion articles covering all aspects of basic and translational cardiovascular research and clinical cardiology: https://www.nature.com/nrcardio

Our June issue is now live, featuring Reviews on: -CKD-associated cardiomyopathy -Molecular imaging of immune and fibrosis targets after MI -Tricuspid valve disease -Cardiovascular pharmacotherapy in older adults with frailty www.nature.com/nrcardio/vol...

New online! Engineered blood clots designed using click clotting technology can rapidly seal bleeding sites #CardioSky

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Nature Reviews Cardiology, Published online: 09 June 2026; doi:10.1038/s41569-026-01315-6In patients with advanced, symptomatic heart failure with reduced ejection fraction refractory to guideline-directed therapy, transplantation of a tissue allograft produced from induced pluripotent stem cells promotes heart remuscularization and leads to increases in heart wall thickness, left ventricular ejection fraction and quality of life at 3 months, according to an interim analysis of the ongoing, phase I–II BioVAT-HF clinical trial.

Nature Reviews Cardiology, Published online: 20 May 2026; doi:10.1038/s41569-026-01303-wIn this Obituary, Peter Libby reflects on the life and achievements of Eugene Braunwald, celebrated as the father of modern cardiology.

Nature Reviews Cardiology, Published online: 21 May 2026; doi:10.1038/s41569-026-01307-6The beating of the heart does more than circulate blood; its rhythmic contractions generate forces to create a biomechanical environment that suppresses tumour growth. This finding, from a new study by Ciucci and colleagues, highlights an underappreciated role for cardiac mechanics in cancer biology.

Nature Reviews Cardiology, Published online: 18 May 2026; doi:10.1038/s41569-026-01300-zDilated cardiomyopathy is a major contributor to cardiovascular morbidity and mortality worldwide, with non-ischaemic aetiology reported in 30–40% of patients with heart failure. In this Review, Ramos-López and colleagues explore the complex epidemiology and genetic architecture of non-ischaemic dilated cardiomyopathy, reflect on the challenges of accurately assessing its prevalence and discuss environmental factors that modify disease penetrance and phenotype.

Nature Reviews Cardiology, Published online: 19 May 2026; doi:10.1038/s41569-026-01305-8Novel engineered blood clots, generated via the rapid crosslinking of red blood cells into tough cytogels, are superior to native blood clots in fracture toughness and adherence to tissues, demonstrating the potential of using ‘click clotting’ technology in the management of haemorrhage, surgical bleeding and bleeding disorders.

Nature Reviews Cardiology, Published online: 28 May 2026; doi:10.1038/s41569-026-01309-4Hypertensive disorders experienced during pregnancy can continue to increase cardiovascular risk after childbirth. However, adequate follow-up (including blood pressure management, risk stratification and cardiometabolic prevention) is not always incorporated into postpartum care. A life-course pathway that integrates surveillance and targeted interventions could reduce inequities and improve long-term cardiovascular outcomes.

Nature Reviews Cardiology, Published online: 27 May 2026; doi:10.1038/s41569-026-01308-5In the randomized, phase II HF-REVERT trial, the miR-132 inhibitor CDR132L was well-tolerated and showed pharmacodynamic target engagement in patients with myocardial infarction and reduced left ventricular ejection fraction, but did not improve ventricular remodelling compared with placebo.

Nature Reviews Cardiology, Published online: 04 June 2026; doi:10.1038/s41569-026-01311-wA new study shows that the microtube network directs cardiomyocyte growth through two mechanisms: by redirecting the localization of mRNA and protein synthesis and by modifying the intercalated disc, the site of cell–cell adhesion at the ends of the cardiomyocyte.