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www.nature.com/articles/s41... Our latest paper in collaboration with Mitch Weiss’s lab. We showed DNA methylation turns off fetal globin expression. I’m still not sure how important methylation is in regulating individual human genes but it represses this one.#sicklecelldisease #crispr #epigenetics
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DNA methylation is a critical component for repression of fetal haemoglobin in adult blood cells. Removing DNA methylation from the fetal haemoglobin promoter effectively upregulates the gene, opening...
Removal of promoter CpG methylation by epigenome editing reverses HBG silencing - Nature Communications
www.nature.com
Merlin Crossley