Developmental Neurobiologist at UZH | Microscopy Enthusiast. Using the chicken embryo to decipher the molecular mechanisms of neural circuit formation. Fascinated by axonal growth cones, primary cilia, and extracellular vesicles.
Alexandre Dumoulin
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Check it out at PNAS today. Thank you Alexandre for the collaboration!!
PK Mem probes offer long time-lapse imaging of cell membrane dynamics. Made possible by
Jing Ling, Yitong Liu, and all the collaborators!
Available @spirochrome.com
Neat trick if you polycolonal ab's suck. Incubate them with fixed cells with a KO of your protein of interest, then spin. Protocol here: www.med.upenn.edu/markslab/ass...
I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands)
#WesternBlot #cellsky
Proximity labeling users: check out this study by @zhixingchen2.bsky.social and Peng Zou, which establishes how much contact-dependence vs. diffusion is responsible for biotinylation — tl;dr TurboID has a much smaller effective radius! www.nature.com/articles/s41... 1/2
Zurich is ready! 🤘 looking forward to hosting you at our Fish and Chicks seminar!
A Sticky Dance Between a Cell and a Neuron. #neuroscience #science #mysterious #HiddenWorld #cell #FluorescenceFriday
➡️A Schwann cell precursor interacting with sensory axons 🔬🧫🧪
Zhixing Chen
This cell migrates along axons and forms repeated adhesive contacts with their growth cones, creating a highly dynamic, almost dance-like behavior. Such contact-dependent interactions are common during nervous system development and help coordinate how cells and axons organize in space.
Very happy to share that my latest submission to the #NikonSmallWorld in Motion competition received an Honorable Mention this year! 🥳 #neuroscience 🧪
Alexandre Dumoulin
This Is What Drives Axon Growth. Axon growth is powered by the actin cytoskeleton at the growth cone.
Here, filamentous actin dynamics drive fast, directed axon extension in real time. #Fluorescencefriday #science #neuroscience #microscopy 🧪
More videos on my YT channel: www.youtube.com/@AlexNeuroHe...
Happy #FluorescenceFriday!
Temporal projection of a time-lapse recording decided to become abstract art. Pretty splashy, isn't it?
PalmBow-labeled commissural axons in culture.
#neuroscience #microscopy #livecellimaging 🧪
Victor Tatarskiy
Alexandre Dumoulin
Alexandre Dumoulin
Jeremy Baskin
Alexandre Dumoulin
A DNA nanoruler platform enables precise measurement of the labeling radii of TurboID and APEX2, uncovering their contact-dependent mechanisms. These findings redefine the enzymology of proximity labe...
