at the LBDV (Laboratoire de Biologie du Développement de Villefranche-sur-mer)
Cnidarian developmental mechanisms group
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These images show live embryos of animals (jellyfish, crustacean, worm, sea urchin, sea squirt, beetle) and one of animals closest single-celled relatives. They were captured taking advantage of fluorescent proteins localised on the outer membrane of cells, allowing us to observe cell outlines. 1/9
So, by providing staged embryo mRNA for this beautiful wide comparative study, we now know that zygotic gene activation in Clytia occurs in the early blastula with 512 cells, at around 5hpf (Here termed ZGA cell cycle 9).
Michalis Averof
This fits the general principle of ZGA being triggered by a 'universal' Genome: Cytoplasm ratio across animals! - and thus a highly conserved mechanism involving titration of a maternal cytoplasmic factor on chromatin.
Cnidarian developmental mechanisms group
More fascinating jellyfish research from Noriyo Takeda, Ryusaku Deguchi and colleagues: A lovely example of speciation in action, as populations of Cladonema pacificum withmorning and evening spawning become reproductively separated. bioone.org/journals/zoo...
www.quantamagazine.org/the-jellies-...
The paper we just published is a collaboration of 12 labs spread across 7 countries, covering sea squirt (shown here), sea urchin, beetle, crustacean, roundworm, ragworm, flatworm, jellyfish, sea anemone & choanoflagellate. Comparing the results identified tags that work well across many species 7/9
Finding molecular tags that localise fluorescent proteins to the cell membrane was the goal of our latest paper, now published in Development @dev-journal.bsky.social. The tags act as address labels, sending proteins to the cell membrane, where they highlight the shape and arrangement of cells. 2/9
Cnidarian developmental mechanisms group
Happy #FluorescenceFriday all!
Checkout these beautiful basal bodies in airway #multiciliated cells expanded via U-ExM 😍
Images captured by the super talented @maneesha07.bsky.social on a #Nikon NSPARC 🔬.
Cnidarian developmental mechanisms group
Cnidarian developmental mechanisms group
Summary: Screening a toolkit of diverse membrane-localising tags identifies candidates that efficiently localise proteins to the plasma membrane in a wide range of animals and choanoflagellates.
Only 1 weeks to apply (April 7) for the joint Master program on "Evolutionary Genomics and Systems Biology" in Vienna.
studieren.univie.ac.at/en/admission...
Cool program with hands-on experience taught by leading scientists in PopGen, EvoDevo, Evolutionary Systems Biology.
Spread it!
Thrilled to present our comparative study on the evolution of zygotic genome activation (ZGA)!! 🥚🧬
Amazing PhD work of @campobes.bsky.social together with @fedemantica.bsky.social and many collaborators! @melisupf.bsky.social @crg.eu. Thread below 1/15
www.biorxiv.org/content/10.6...
studieren.univie.ac.at
www.biorxiv.org
Moe Mahjoub
Then, what determines ZGA onset?? We correlated multiple genomic, developmental and ecological features with ZGA timing and, cutting to the chase, we found that the log ratio of genome size vs. egg volume very strongly scaled negatively with ZGA onset in cell cycles! 7/15
Manuel Irimia
Manuel Irimia
www.quantamagazine.org
Off the coast of Japan, biologists netted a pea-size jellyfish with an unusual circadian clock — a chance finding that suggests there are likely more overlooked biological timekeeping mechanisms to be...
