Enjoyed this recent review/perspective: many somatic mutations are already present in normal tissues, shifting attention from driver mutations to non-mutagenic promoters of oncogenesis. Also wild that it took 3 years from submission to publication. nature.com/articles/s41586-026-10386-x
nature.com
This Review revisits tumour initiation and promotion in light of clonal diversity and the presence of cancer driver mutations in normal tissues, aiming to understand mechanisms that enable environment...