This study builds on PACIFIC, our computational method for detecting clinically important multi-omics interactions (aacrjournals.org/mcr/article/...). Here, we extend this interaction-based framework to discovery of prognostic signatures defined by pairs of genomic alterations. [4/4]
AbstractOncogenesis, tumor progression, and therapy response are shaped by somatic alterations in the cancer genome and features of the tumor-immune microenvironment (TME). How interactions between th...
