Really important discussions yesterday between our lab and @davidlvbauer.bsky.social . Thanks for hosting us at the Crick for a triple lab meeting with the Malquer lab!
Dalan Bailey
Our first post on here and it's a doozy 😍🤩. Our epic piece on #sarbecovirus host range. #virology #sars2 #covid #vaccines. Enjoy and please repost. www.biorxiv.org/content/10.1...
Took a long time to get this done, 2-3 years on Figure 1 alone but glad it's finally out!! www.nature.com/articles/s41...
And the sister paper from collaborator and good friend Katie Doores ... A deeper dive into how some of these broadly neutralising #sarbecovirus #coronavirus #sars2 #covid antibodies actually work www.biorxiv.org/content/10.1...
Human CEACAM6, which is widely expressed in the lung, is identified as a receptor used by the spike proteins of Cardioderma cor (heart-nosed bat) alphacoronaviruses to enter cells.
A study in Nature finds that a subset of bat alphacoronaviruses (a major group of coronaviruses) has the potential to enter human cells by exploiting a previously unknown cellular gateway. 🧪
Dalan Bailey
My colleague @socialinfluenza.bsky.social has written an absolutely excellent explainer for @theconversation.com about our recent paper with @dalan-bailey.bsky.social identifying a new human surface receptor for alphacoronaviruses:
theconversation.com/scientists-h...
Nature Portfolio
Stephen Graham's Lab
Human CEACAM6, which is widely expressed in the lung, is identified as a receptor used by the spike proteins of Cardioderma cor (heart-nosed bat) alphacoronaviruses to enter cells.
The continuing evolution of SARS–CoV–2 variants of concern, and the increasing spillover potential of sarbecoviruses into the human population presents an important and urgent need to discover cross-r...
Sarbecoviruses interact with their receptor, angiotensin converting enzyme 2 (ACE2), via the receptor binding domain (RBD) of Spike, the immunodominant target for neutralising antibodies. Understandin...
