Cell biologist and immunologist.
Group Leader at MRC LMB @mrclmb.bsky.social
🧪 Dendritic cells, antigen presentation, endocytic escape
Patrycja Kozik
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Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
I have a PhD position available with start date September 2026 at the University of Manchester.
Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes
Due to funding requirements, this position is for UK home students only.
www.findaphd.com/phds/project...
We are thrilled to share our new pre-print on the molecular anatomy of nuclear proteasome in human sperm cells! #In-cellcryo-ET + #SPA + #LM! @piotrkolata.bsky.social @a-dsantos.bsky.social, @tomdendooven.bsky.social!! doi.org/10.64898/202...
How does a macrophage decide to eat or simply nibble? Check out our latest paper! You can also read this nice review. Congrats Caitlin for leading this amazing work!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Happy to share a new preprint from our lab, uncovering "spooky action at a distance" - for RNA Polymerase II:
www.biorxiv.org/content/10.6...
Day 24 of making proteins for #ArtAdventCalendar
The nuclear pore complex is a huge pore made of hundreds of proteins, that allows the flow of nucleic acids and proteins between the nucleus and cytoplasm. It also looks like a wreath!
Merry Christmas!
More projects: e-nox.net/portfolio/
#SciArt
I am excited to share that our work, in which we have dissected the signals driven by the nucleoside-modified mRNA and LNP components of mRNA vaccines that regulate germinal center (GC) responses, is now published in Cell! www.cell.com/cell/fulltex...
Day 6 of making proteins for #ArtAdventCalendar
This is a "nanodisc", which is a tiny section of lipid membrane, just big enough to hold a single membrane-bound protein, and holds the structure stable enough to probe its structure
More projects: e-nox.net/portfolio/
#SciArt
Absolutely delighted that our latest paper is out today @natimmunol.nature.com. It has taken five years to uncover a role for cross-presentation in shaping the immune visibility of tumour antigens. A labour of love led by @drjonlim.bsky.social and Oliver Schulz. Great start of 2026!
PhD Project - Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes at The University of Manchester, listed on FindAPhD.com
Cornell et al. show that target cells with low cortical tension induce macrophages to preferentially trogocytose, or engulf in small fragments, whereas target cells with high cortical tension tend tow...
www.nature.com
DNA is scattered with obstacles that stall RNA polymerase II (Pol II) and block the production of full-length transcripts. Two mechanisms are known to resolve stalled Pol II: transcription-coupled nuc...
This study dissects the individual contributions of the different components of mRNA
vaccines to immune responses. Nucleoside-modified mRNA promotes the production of
type I interferons that act on de...
My "News & views" was published today @natmethods.nature.com
Thanks @ritastrack.bsky.social for the invitation to write it and Allison Doerr for the editing after Rita left...
www.nature.com/articles/s41...
