An international, peer-reviewed Thieme journal in #chemicalsynthesis, founded in 1969, publishing #reviews and #fullpapers.
🔗 https://www.thieme.de/synthesis/journal-information-55920.htm
Synthesis Journal
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#Electrochemistry enables selective iodination of challenging arenes⚡In this work by Gerhard Hilt & co-workers, a tunable I₂/Cl⁻ system delivers highly regioselective meta #iodination of electron-deficient #arenes 🔬 A controllable and versatile synthetic strategy💡
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Synthesis Journal
What if we could functionalize the unreachable positions in molecules?⚡ In this review by Ikuya Fujii & Ryo Shintani, 3d metals enable through-space 1,n- #migration for remote, site-selective bond formation🔬
#organometallic
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Purifying complex #biocatalytic mixtures—without the headache? 🧪⚡ Jung, Moor & co-workers use a vision-guided automated #HTE platform to optimize liquid–liquid extraction 🔍 Achieving 93% recovery of a macrocyclic peptide with no protein residue🔍
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In this review by Yong Sun Park, recent advances in catalytic 1,2-elimination are discussed for accessing diverse chiral frameworks🔬 From #desymmetrization to #KineticResolution, these pathways highlight the growing sophistication of elimination-based asymmetric design
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Can #gold catalysts unlock precise control in complex cyclizations?✨ Clisson & Michelet @vmichelet06.bsky.social highlight enantioselective Au-catalyzed #cycloisomerization of 1,6-enynes, delivering bicyclic scaffolds with high chemo, regio, and stereocontrol🚀
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What if light could unlock new reactivity in simple molecules?⚡Jung Woon Yang & co-workers present an innovative #photoredox approach that enables precise bond formation under mild conditions, broad scope, high selectivity & new possibilities for synthesis
#organocatalysis
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🧪Unlock the future of #selenium chemistry with Wang & Yang✨ Explore the latest advances in asymmetric #hydroselenation & selenofunctionalization — from chiral catalysts to photo/electrocatalysis 🚀 Tackling low-reactivity alkenes and stereocontrol remains the next challenge🔬
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What if we could build complex bioactive molecules with near-perfect precision?🔬 The last 5 years unlocked >95% ee and >90% yields in asymmetric synthesis of benzofused heterocycles, powered by metal #catalysis, #organocatalysis & #photoredox by Zhang & Ma 🚀
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What if #Birch reductions could be faster, cleaner, and solvent free?🧪 #Mechanochemistry enables rapid 30 min debenzylation using simple sodium lumps, where Ito @hajito1.bsky.social & co-workers show no ammonia, no inert gas, no bulk solvents needed 🚀
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What if you could build C–S and C–O bonds in one elegant step?🧪 Bicic & Oestreich @silicon-martin.bsky.social showcase a #photoredox strategy for regioselective difunctionalization of #styrenes under mild, redox-neutral conditions powered by a radical–polar crossover✨
#oximes
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