Thrilled to share our new review online with
@scottvedwards.bsky.social in @Trends Ecol & Evo! “pangenomics is rapidly transforming our ability to dissect the genetic basis of ecological and evolutionary change in natural systems.”
Ver excited to share my just-published Darwin Review with @lh3lh3.bsky.social on population-scale long-read sequencing! royalsocietypublishing.org/rspb/article...
Abstract. Population-scale long-read DNA sequencing (PLRS) is rapidly reshaping our understanding of genomic variation in humans and non-model species. In
Online now: Pangenomes: new tools for ecological and evolutionary genomics
I am looking for a postdoc to develop high-performance algorithms in computational genomics. Email or DM me if interested. For more information, see hlilab.github.io/vacancies. RTs appreciated!
Congratulations, Wendy!🎉🎉
Our new preprint @scottvedwards.bsky.social 🧬🐦 Long-read genomes show songbird germline-restricted chromosomes (GRCs; expelled from somatic cells) are 70 % repeats and packed with active LTR retroviruses. A hidden reservoir for TE-driven innovation/diversification! www.biorxiv.org/content/10.1...
Happy to share our new paper "Inferring Species Trees" led by @scottvedwards.bsky.social, which overviews coalescent models and methods for species tree inference. 📚 doi.org/10.1016/B978...
How does population size shape the dynamics of structural variants across the genome?
Check out our new paper in @science.org www.science.org/doi/10.1126/...
Genomic structural variation is an important component of genetic variation in natural populations. By assembling and analyzing multiple high-quality genomes within a species or clade, pangenomes capture variation that can be missed by reference-based genomics at both the sequence and the genic levels. Although pangenomes are nascent tools for animals compared with other taxa, they have already unveiled novel insights into genome evolution, adaptation, the genomic basis of organismal traits, and conservation genomics. We highlight the rapid progress and unique ecological and evolutionary discoveries emerging from applying pangenome tools to diverse natural populations. We conclude that pangenomes are fundamentally shifting the field by revealing structural variants as a key source of adaptive potential and genomic diversity previously missed by single-reference methods.
Incorporating SVs into conservation genomics can improve our understanding of population health and resilience. 🌿🔬
Paper here: doi.org/10.1093/jher...
Lab website: edwards.oeb.harvard.edu
#JHered #Conservation
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Trends in Ecology & Evolution
Please check out the newly published Murphy lab’s new paper in @nature.com! www.nature.com/articles/s41...
