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by @jimpick.com
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📖 Happy to share our recent preprint! www.biorxiv.org/content/10.1... We discovered how SINEs are kept silent: the ChAHP protein complex acts as a molecular brake on POL III transcription retrotransposons. A 🧵:
11mo
www.biorxiv.org
Short interspersed nuclear elements (SINEs) are abundant non-autonomous transposable elements derived from RNA polymerase III (POL III)-transcribed short non-coding RNAs. SINEs retain sequence feature...
ChAHP Silences SINE Retrotransposons by Inhibiting TFIIIB Recruitment
Jakob Schnabl-Baumgartner