Prof. of Comparative Genomics @ Senckenberg Frankfurt; Genomics, Evolution, Comp Bio & the Phenotype-Genotype Question.
https://hillerlab.com
Michael Hiller
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And we extended the TOGA2 resources to
- 1011 placental mammal assemblies, covering 788 different species.
- 20 marsupial / monotreme species,
- 865 bird assemblies, covering 812 different species.
All data on genome.senckenberg.de/download/TOG...
I hear you want novelty🦎->🐢,
chromosome evolution 🧬,
sex determination🩷,
link population history📈 & climate🌏🌡️?
Or you share my love for wonderfully weird animals?
Side-necked turtle genomes reveal chromosomal dynamics, skeletal innovation and cancer resistance
www.biorxiv.org/content/10.6...
A 🧵
Michael Hiller
I wrote a short Nature Methods News & Views piece on deep learning based gene finders such as ANNEVO. www.nature.com/articles/s41...
Leon Hilgers
Happy to announce the release of TOGA2 data for 68 turtle genomes, generated with a cryptodiran and a pleurodiran turtle reference. The combined TOGA2 annotation consistently improves annotation completeness compared with RefSeq. All data at genome.senckenberg.de/download/TOGA2. Genome browsers ...
Clicking on a transcripts opens a page with more information
Annevo uses deep learning to achieve unprecedented accuracy in eukaryotic gene annotation, approaching the performance of evidence-based methods.
www.nature.com
We now have genome browsers on our UCSC mirror at genome.senckenberg.de for the 1033 mammal and 866 bird assemblies, showing spliceAi, reference-based and ref-integrated TOGA2 tracks.
Tables with links to all browsers are genome.senckenberg.de/TOGA2Mammali... & genome.senckenberg.de/TOGA2Aves.html
at genome.senckenberg.de/TOGA2Testudi... Credits to @bernhardbein.bsky.social @leonhilgers.bsky.social and @ymalovichko.bsky.social.
Yury Malovichko et al. "Accurate, comprehensive gene annotation and ortholog identification across thousands of vertebrate genomes with TOGA2", in preparation
