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Senior Scientist, Professor & Program Director @ OHRI & uOttawa 🇨🇦. Fascinated by vascular & metabolic causes of neurodevelopmental disorders, SciArt and the night sky 🔬 🎨 🔭 Follow for 🧪 news and more! Look for #cerebrovascular
Baptiste Lacoste









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Save the date 😎 #CSHL #BBB
8d
Look at this beautiful preprint ! by Neil Dani & team #ChoroidPlexus #BrainBarrier www.biorxiv.org/content/10.6...
New study clarifies the role of Angiopoietin 2 in the brain vasculature #Cerebrovascular 👇
Baptiste Lacoste
2mo
1mo
New results show that, in addition to neural changes, sleep involves nonneural processes such as vasomotor-driven hydrodynamic waves 🤩 #Cerebrovascular #sleep
Amazing paper by Andrew Yang's lab using a new, a non-invasive genetic system to trace neuron-derived protein clearance from the brain to cerebrospinal fluid and border tissues 🤩 #cerebrovascular www.sciencedirect.com/science/arti...
New paper by @caglaeroglu.bsky.social ! #astrocytes #development
The absolute dream paper for any #cerebrovascular developmental biologist !! Congrats to @nicolasrenier.bsky.social, @alexdubrac.bsky.social and their teams !
New insights into brain imaging by @annadevor.bsky.social just dropped 🧠✨ This study shows that neuromodulators, especially norepinephrine, actively reshape how neural activity translates into blood flow signals across the cortex. A powerful step toward more accurate brain mapping! #cerebrovascular
Our cerebrovascular symposium @canacn.bsky.social in Montreal was a blast with full room! Thanks Aurélie, Grant, Ravi and Alex for your fantastic talks! May the vessels be with you 💪 #symposium #CanadianNeuroscience #cerebrovascular
2mo
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Baptiste Lacoste
2mo
17d
Very happy to share our latest work out in PNAS this week, led by Amy Xiang. We show that capillary thin-strand pericytes express TMEM16A calcium-activated chloride channels, which set the operating point for capillary control of cerebral blood flow in vivo. www.pnas.org/doi/10.1073/...
Baptiste Lacoste
1d
Baptiste Lacoste
Baptiste Lacoste
Baptiste Lacoste
Baptiste Lacoste
Baptiste Lacoste
Baptiste Lacoste
Tom Longden
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
meetings.cshl.edu
Brain Barriers
www.biorxiv.org
Sakers et al. report that astrocytic NLs are functionally diverse proteins with unique intracellular protein–protein interactions. They show that Nedd4l bidoi.org
Sleep is essential for maintaining brain tissue homeostasis, which is facilitated by enhanced cerebrospinal fluid (CSF) solute transport. Infraslow...
www.pnas.org
Sleep alters neurovascular and hydrodynamic coupling in the human brain | PNAS
Neuroligin-2 is ubiquitinated by Nedd4l to control developmental astrocyte morphogenesis
www.cell.com
Whole-brain tissue clearing and spatial transcriptomics were applied to map postnatal vascular development in the mouse brain, identifying three coordinated phases that link vascular growth to neurona...
The spatiotemporal dynamics of postnatal vascularization in the mouse brain
A new optical imaging study demonstrates that norepinephrine and the state of arousal influence hemodynamic correlations across cerebral cortex, calling for a conceptual shift in interpreting function...
www.nature.com
The neurovascular impulse response function differentially reflects intrinsic neuromodulation across cortical regions - Nature Neuroscience
2mo
Angiopoietin 2 promotes vascular permeability in peripheral organs, but its role in brain is unclear. doi.org/10.1172/jci.... Li et al. show ANGPT2 loss in mice leads to region-specific brain malformations and blood-brain barrier leakage.
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