Ever felt constrained by the "4-color limit" in fluorescence imaging?
We use DNA-barcoded labeling to build high-plex panels, enabling imaging of 15 targets across the full fluorescence spectrum.
doi.org/10.64898/202...
Grateful to @sinemsaka.bsky.social and all authors for making this possible.
2/ ProPER implements in situ proximity extension by leveraging primer exchange reaction. The hairpin extends its cognate primer when they are in physical proximity. Proximity-encoded DNA barcodes are recorded into single stranded DNA concatemers, which are read out by fluorescent oligos @embl.org
1/ ProPER - Our novel ligation-free proximity detection method for efficient multiplexed imaging of molecular interactions in situ. Among other things we use it to image the life cycle of RNA molecules and resolve differential kinetics of gene expression steps. New preprint: doi.org/10.64898/202...
Want to acquire #ExM images like this and help us understand the true extent of cytoskeletal diversity across the tree of life? This position might be for you!
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
With @dudinlab.bsky.social
@embl.org @biology-unige.bsky.social @moorefound.bsky.social
You might have noticed lots of activity in the napari project recently! 🚀 We're grateful for a grant from CZI that's keeping us going, but grants don't last forever: we're trying to figure out sustainable long term funding. Read our blog post to find out how you can help:
napari.org/island-dispa...
We present a versatile microfluidics platform that makes multiplexed super-resolution imaging more accessible, reproducible, and high-throughput.
👉 BioRxiv: www.biorxiv.org/content/10.1...
#SuperResolution #DNApaint #Microfluidics #SMLM #OpenScience #multiplexing
Kristina
We are hiring a Research Software Engineer to enhance and maintain the SpatialData framework.
We will work together with colleagues at EMBL, DKFZ, GSK, and across the scverse community.
🔗 Deadline: 15/02/2026
embl.wd103.myworkdayjobs.com/en-US/EMBL/d...
To all post-docs: The Genome Biology dept @embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Whole-brain connectomes are rare and expensive “hero datasets.” 🧠 Dr. Sven Truckenbrodt explains why cost and scalability limit comparative #connectomics, and why that matters for #neuroscience.
Check out the full episode here: youtu.be/a4qpFpjnOX4
Video
Jorge Trojanowski
Jorge Trojanowski
Highly efficient 12-color multiplexing with speed-optimized DNA-PAINT. We are excited to share our latest paper in @natcomms.nature.com, using left-handed DNA to extend speed-optimized DNA-PAINT to 12 targets in a simple and straightforward way! 🧬👈🚀https://www.nature.com/articles/s41467-025-64228-x
