Junior group leader in neuroscience - calcium imaging, ephys, plasticity, microscopy, neurons & astrocytes, data analysis. PhD with Rainer Friedrich, postdoc with Fritjof Helmchen. https://www.gcamp6f.com/
Peter Rupprecht
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My review focuses on a point where data and interpretations across labs seem to diverge: the prevalence and importance of dendritic calcium and voltage events decoupled from the soma. I'd be interested in hearing more opinions on that!
🧪 1/ New preprint from the lab: L5 pyramidal cell tLTD requires astrocyte Ca2+ and CB1 signaling
www.biorxiv.org/content/10.6...
We revisit a classic STDP result in visual cortex
In this new blog post, I review some several recent studies on dendritic voltage and calcium imaging in hippocampus: gcamp6f.com/2026/05/19/d...
Great work by @bhlee1117.bsky.social, Xiang Wu, @adamezracohen.bsky.social, Attila Losonczy, Balazs Rosza, Kevin Gonzalez, and others!
We're thrilled to share this #Perspective @natneuro.nature.com
on #astrocytes as a multilayered system of #functional #units that operate across spatial scales.
👉Available for reading here:
rdcu.be/fk0B7
👉Full article here:
www.nature.com/articles/s41...
Finally online @natmethods.nature.com
www.nature.com/articles/s41...
This was a fun collaboration with @finkryan.bsky.social @massecklab.bsky.social @tpatriarchi.bsky.social @martinfuhrmann.bsky.social @campbell-lab.bsky.social @jangrundemann.bsky.social
🧪🧠🔬🧬
1/8. New preprint!
Using fUSi in head-fixed mice🐭, we found that arousal events trigger a brain-wide wave of activity 🌊🧠.
Surprisingly, this pattern was preserved during opto manipulations of the locus coeruleus, pointing to a minor role for noradrenergic tone.
www.biorxiv.org/content/10.6...
Delighted to share our discoveries about one of the brain's neurotransmitter systems:
www.biorxiv.org/content/10.6...
Together with colleagues at the @alleninstitute.org, we have learned a lot about a tiny cluster of neurons in the brainstem locus coeruleus (LC) that releases norepinephrine (NE). 1
Two-photon calcium imaging at 24,000 lines/s, with the resonant axis spanning 4x what other systems can do. Inertia-free. Diffraction-limited. No tradeoffs. Che-Hang Yu developed a 4x angle multiplier for laser scanning. His paper is out today: opg.optica.org/optica/fullt... 1/n #fluorescenceFriday
First whole-brain recording of social sound processing in a vertebrate. Surprises start in the hindbrain; thalamus gates conspecific calls; male and female brains diverge downstream. Work by @joerghenninger.bsky.social, @mh123.bsky.social sky.social and team. www.biorxiv.org/content/10.6...
Two brain circuits.
Same learning problem.
Shared learning outcomes.
Different dynamical implementations.
Our work shows that learning is not a single canonical solution but can emerge through distinct population dynamics shaped by circuit architecture.
Excited to share our latest preprint! 🧵1/12
Peter Rupprecht
Peter Rupprecht
Jesper Sjöström
João Filipe Oliveira
Emilie Macé
Jonas Wietek
Spencer LaVere Smith
Jeremiah Cohen
Benjamin Judkewitz
Flavio Donato
PinkyCaMP is a red genetically encoded calcium indicator with improved brightness and photostability. Derived from mScarlet, it does not exhibit photoswitching upon blue light illumination and is ther...
Equivalent volitional learning emerges through circuit-specific population dynamics in motor cortex and hippocampus https://www.biorxiv.org/content/10.64898/2026.06.04.730137v1
