Cognitive Neuroscientist | #Memory & #Sleep | from single neurons to sleep oscillations in humans | http://schreiner-lab.com, Trinka-Lab and with Mormann-Lab.
Fabian Schwimmbeck
Loading...
đź””PREPRINT: Sleep ripples drive single-neuron reactivation for human memory consolidation
1/9: How does sleep support human memory consolidation? To test this, we recorded hundreds of neurons in the human medial temporal lobe (MTL) across learning, wakefulness, and sleep.
doi.org/10.64898/202...
5/5
Neuronal co-activation peaks when SWRs couple to cortical slow-oscillation–spindle complexes, highlighting the cortex’s active role in shaping hippocampo-cortical communication during memory consolidation.
#sleep #memory #bluskience
4/5
SWRs selectively co-reactivate experience-related concept neurons in the hippocampus and downstream remote areas.
Episodic memory consolidation by reactivation of human concept neurons during sleep reflects contents, not sequence of events https://www.biorxiv.org/content/10.64898/2026.01.10.698827v1
3/5
Cortical slow oscillations and sleep spindles actively shape conditions for optimal hippocampal information transfer, structuring medial temporal lobe firing dynamics during sleep.
2/5
We show that hippocampal SWRs drive a directed hippocampal-to-cortical information flow at the single-neuron level, with latencies scaling with distance from the hippocampus.
How does the brain replay memories during sleep?
Excited to share our new preprint, the outcome of an extensive effort led by Johannes Niediek, showing that reactivation of human concept neurons reflects memory content rather than event sequence.
How are memories consolidated during sleep?
Excited to share another preprint: hippocampal SWRs route memory content to the cortex via interregional co-reactivation of concept cells, optimized by slow-oscillation–spindle coupling. With the great @tschreiner.bsky.social @humansingleneuron.bsky.social
Last week to apply! Cognitive Neuroscience Research Laboratory Manager at @oxexppsy.bsky.social (with links to @oxcin.bsky.social and @ox.ac.uk)
www.jobs.ac.uk/job/DPZ833/c...
📢 New paper out in @nathumbehav.nature.com:
we identify a previously undescribed fast thalamic oscillation (~19–45 Hz) in rare intracranial human recordings that appears specifically during wakefulness and REM sleep — but disappears during NREM sleep.
www.nature.com/articles/s41...
doi.org
Check out jobs.ac.uk for opportunities in professional services, including Cognitive Neuroscience Research Laboratory Manager. Apply today and learn more about the role.
