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ZNF274 loss shown to drive a classical to basal transition in #pancreatic #cancer via suppression of ZEB1 and HERV-driven interferon signaling, increasing the sensitivity to CDK7 inhibition doi.org/10.1038/s414...
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Pancreatic ductal adenocarcinoma (PDAC) classical and basal subtypes can interconvert. Here, the authors discover that ZNF274 loss drives a classical to basal transition in PDAC via suppression of ZEB...
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ZNF274 constrains lineage plasticity and drives intrinsic resistance to CDK7 inhibitors in pancreatic cancer - Nature Communications
Nature Communications