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Postdoctoral researcher at @radaiglesiaslab.bsky.social | Developmental genomics | preLighter (The Company of Biologists) | Artistic & Creative | Passionate about visual storytelling and design
María Mariner









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🚨Happy to share a new PreLight covering the latest #preprint by the Meissner lab (@molgen.mpg.de) on acute SUZ12 degradation during TLS formation. A work brilliantly executed by @dannimklee.bsky.social et al. Get to know more about him and his work here ⤵️ prelights.biologists.com/highlights/t...
23d
Pairing acute SUZ12 degradation + simplified embryoids, Ming-Kang Lee et al. pinpoint time-dependent sensitivities to PRC2 loss. A meticulous experimental approach applicable to the functional stage-s...
prelights.biologists.com
Temporal degradation of PRC2 uncovers specific developmental dependencies - preLights
María Mariner
This is a fascinating paper that reveals defined and clear mechanism for a phenomenon that for some seemed unbelievable- the up regulation of genes paralogous to those with specific types of inactivating mutations. This is called transcriptional adaptation 1/ www.science.org/doi/10.1126/...
3mo
This graph basically shows that the MSCA are, as of now, useless unless the EU governance does something about it 🧪
Our latest: Minimal essential requirements for neural tube self-organisation How does a single cell give rise to a tissue with the right cell types in the right proportions? We deconstruct and rebuild a self-organising tissue from first principles A thread🧵 www.biorxiv.org/content/10.6...
Ahead of International Women’s Day on March 8, we’re sharing the female scientific role models who inspire our colleagues—one per day. Today Postdoc Irene Talon from the Vallier Lab. #InternationalWomensDay #IWD2026 #WomenInScience
4mo
3d
3mo
Craig Kaplan
Out now in Science! Our study challenges long-standing assumptions about transcription factor specificity in eukaryotes. Novel single-molecule measurements of TF behavior in living cells reveal an independence of locus-specific binding from DNA sequence recognition.🧵 www.science.org/doi/10.1126/...
The reliable generation of diverse cell types in precise proportions is essential for the formation of functional tissues during embryonic development. Three-dimensional organoid models derived from p...
Minimal essential requirements for neural tube self-organisation
www.biorxiv.org
In full agreement with this Career Feature article by @keepitonthehdl.bsky.social for @nature.com: www.nature.com/articles/d41... Turia came into our lives right on time, and she brought light, fun, and so many wonderful hikes! 🐕🏔️💙@sanchezgaya.bsky.social
There are so many fun ways to approach research dissemination! Tried the @prelights.bsky.social spotLight video format to share our latest published work on how ZIC2 shapes early neural development! Total YouTuber vibes: and I kinda' loved it, tbh. 🤳🔬👇 youtu.be/V_yMoWMkZCM
Orgullo de empollona, por Delia Rodríguez elpais.com/opinion/2026... @elpais.com
MadScientist
James Briscoe
9d
Max Planck Institute for Molecular Genetics
el apoyo a las familias afectadas y el impulso a la investigación científica que permita mejorar el diagnóstico, el tratamiento y la calidad de vida de quienes conviven con estas patologías. #diamundialenfermedadesraras #rarediseasesday
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3mo
3mo
How intrinsically disordered regions (IDRs) shape chromatin binding and nuclear organization of transcription factors (TFs) remains unclear. We used proximity-assisted photoactivation (PAPA), a single...
www.science.org
Unstructured transcription factor interactions enable emergent specificity
YouTube video by The Company of Biologists
youtu.be
spotLights Ep 21: María on how ZIC2 shapes neural development #neuroscience #science #biology
Transcriptional adaptation (TA) is a genetic robustness mechanism through which mutant messenger RNA (mRNA) decay induces sequence-dependent up-regulation of so-called adapting genes. How cytoplasmica...
www.science.org
Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation
María Mariner
María Mariner
Tjian + Darzacq Lab, UC Berkeley
Irene Vallejo
Ada García
the cutoff scores for #MSCA postdoc fellowships are very high this year. has the score distribution shifted compared to previous years? I made a plot with scores from past years. if scores are at ceiling level, the process becomes essentially a lottery, because minor issues can lead to deductions.
4mo
Natalie Schaworonkow