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Professor, Physiology Department, Perelman School of Medicine, University of Pennsylvania. https://www.lakadamyali-lab.com Super resolution microscopy, single molecule biophysics, microtubules, organelles, nucleus and chromatin
Melike Lakadamyali
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Heterogeneity of late #endosome/#lysosomes shown by multiplexed DNA-PAINT imaging. Quantitative pipeline developed by Charles Bond, Melike Lakadamyali @melikel.bsky.social and colleagues: rupress.org/jcb/article/... 📕 Part of #Lysosomes 2026: rupress.org/jcb/collecti...
12d
In unpublished work with collaborators (soon to come) we also show that mitigating aberrant chromatin remodeling events identified by O-SNAP can partially rescue cell function.
This work was driven by a very talented graduate student in the lab, Hannah Kim, and numerous, amazing collaborators who contributed with biological model systems.
Journal of Cell Biology
9d
9d
I am so happy to see our paper on spatial feature based analysis of chromatin states in print in Nature Communications. Here is an early access version of O-SNAP: www.nature.com/articles/s41...