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Behavioral neurologist at Stanford University caring for patients with Alzheimer’s disease and related disorders like Lewy body disease. My lab studies the genetics of these disorders looking for novel drug targets. #Alzheimer's #publichealth #neuroskyence
Mike Greicius









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#birds #birding #goldfinch #bluebird Communal bathing on the engineering quad.
8d
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Mike Greicius
#coyotes #stanford Two coyote sitings on two days at Lake Lagunita. But two coyotes or same coyote? First one looks a bit mangier but cannot convince myself one way or the other.
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#trump #archdetrump #politics Fantastic public comments to the National Capital Planning Commission on Trump's "garish", "grandiose", "ugly", "unoriginal", "too tall", "galling", "egotistical"... arch. Descriptions of potus also great: "litte-minded", "morally-underdeveloped"... tinyurl.com/v9mra3f4
#mimicry #camoflage #leafbug I am neither a bug specialist nor a leaf specialist, but this bug looks a lot like a leaf.
6d
#bunny #rabbit #timelinecleanse Bunnies and birdsong
Mike Greicius
2d
#bunnies #venogram #rabbit #bunny Bunnies coming and going. Nice ear vasculature silhouettes at the beginning. Sun-fueled venogram.
🧪 #alzheimer #amyloid Amazing new paper from @sfackley.bsky.social that exposes the statistical alchemy Lilly applied to their donanemab data: jamanetwork.com/journals/jam... There is little to no correlation between amyoid removal and clinical outcomes with donanemab (or lecanemab).
Lilly used "quantile-aggregation" to transform individual level data with 100s of data points and a correlation of 0.08 (see figure) into 10 data points with a correlation of 0.87! Dr. Ackley clearly debunks this approach with simulations and real-world data. Check it out. Spread the word.
#birds #birding #spottedtowhee #towhee #stanford Spotted towhee dusk song.
www.ncpc.gov
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Mike Greicius
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Mike Greicius
jamanetwork.com
This study evaluates the quantile-aggregation method using both simulated data and publicly available Alzheimer disease randomized trial data.
Methodological Considerations for Quantile Aggregation in Alzheimer Disease Trials
Mike Greicius
Mike Greicius
Mike Greicius
Mike Greicius
Mike Greicius
#thecomeback #Friends #lisakudrow #beatles Lisa Kudrow's amazing work on The Comeback (all 3 seasons) cements her reputation as the George Harrison of Friends.
12d