Super thrilled to see our review out! It was a great experience to put this together with @sameerthukral.bsky.social and @yuchiunwang.bsky.social. Use it as a primer to the field or as inspiration to brainstorm how rigidity transitions can bridge scales!
Our heroes: Bipasha Dey in my lab, Verena Kaul and @girishkalephd.bsky.social in Steffen's lab. PI search committees: be on the look out for Bipasha and Girish. They do wonders. But not after Bipasha does some additional cool things with Pavel. Stay tuned! (6/9)
Our recent preprint on how elevated temperatures affect early embryo development. We are using fly embryos to address this fundamental question, and seeing mitotic defects, which can be rescued to improve embryo survival.
doi.org/10.1101/2023...
A mechanical puzzle solved: @lepuslapis.bsky.social and @zhaoshh.bsky.social lay the foundations for mechanical instabilities on curved surfaces. @mpi-cbg.de @mpipks.bsky.social @csbdresden.bsky.social, publication in @physrevlett.bsky.social: www.mpi-cbg.de/news-outreac...
Yu-Chiun Wang
Girish Kale
Missing also @bipashadey29.bsky.social, but with @sameerthukral.bsky.social crashing the party, more than making up for it!
Max Planck Institute of Molecular Cell Biology and Genetics
Happy to have shared my first post on The Node, on how hidden power dynamics may prevent creative science from blooming.
@the-node.bsky.social
thenode.biologists.com/the-invisibl...
Tissues transition between solid & fluid states in development & disease; cytoplasm turns crowded or inert to literally 'solidify'. Any connections? Turns out nothing's known. @sameerthukral.bsky.social & @bipashadey29.bsky.social pulled this review off brilliantly with a conceptual synthesis.
Final thanks to reviewers @amartinezarias.bsky.social @thibautbrunet.bsky.social & Cassandra Extavour and the editor @endofthepier.bsky.social. Quest for the mysteries of #cephalicfurrow and #Evolution_of_Morphogenesis continues (9/9)
Excited to share our new review in Development, Growth and Differentiation(DGD) Journall!
With the amazing @yuchiunwang.bsky.social & @bipashadey29.bsky.social,we explore how rigidity transitions bridge cytoplasmic & tissue scales.
Read the full review: onlinelibrary.wiley.com/doi/full/10....
I'm a big fan of podcasts, and one of my favorites is Tim Harford's "Cautionary Tales." It tells true stories about disasters and what we can learn from
Two distinct solutions, out-of-plane deformation and out-of-plane division, prevent mechanical instabilities. Our paper www.nature.com/articles/s41...; Pavel's and @bruvellu.bsky.social's with beautiful HCR in situ, lightsheet and @carldmodes.bsky.social's model www.nature.com/articles/s41... (5/9)
Yu-Chiun Wang
Multicellular organisms generate organizational complexity through morphogenesis, in which mechanical forces orchestrate the movements and deformations of cells and tissues, while chemical signals re...
Our latest manuscript on (Harry Potter and) the effect of elevated temperature on embryonic development in flies. Even a small increase in temperature causes developmental defects, indicating problems in the face of global warming! www.nature.com/articles/s41...
Researchers lay the foundations for mechanical instabilities on curved surfaces.
Kale et al. show that nuclear divisions are defective at elevated temperature, leading to gastrulation defects and embryo lethality. Their work finds that F-actin – microtubule interactions during mit...
Temperature variations can challenge animal survival, with different life cycle stages presenting distinct vulnerabilities to elevated temperature. Here, embryonic development is known to be especiall...
