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My colleague sent me this paper and said she missed her bus stop reading it. I opened the link and was pleasantly surprised to see it’s a game-changing paper from a great team! Congrats!
May 2, 2025
Chrystal Starbird
Excited to see this out in @science.org today!! www.science.org/doi/10.1126/...
May 1, 2025
www.science.org
The ability to study proteins in their native cellular context is crucial to our understanding of biology. In this work, we report a technology for intracellular protein editing, drawing from split in...
Intracellular protein editing enables incorporation of noncanonical residues in endogenous proteins
George Burslem
Ever wanted to edit a protein sequence inside a living mammalian cell? Maybe to site specifically incorporate a non-canonical residue? Perhaps you’d like to do a pull down without an antibody? Or use a small molecule fluorophore to image an endogenous protein? 1/4