Postdoc at @idisba.bsky.social.
🔬 Developing 3D BBB models.
PhD with @xaviertrepat.bsky.social at @ibecbarcelona.eu & MSc with @ClaudioAFranco1 at @gimmfoundation.bsky.social
Isabela Corina Fortunato, PhD
Paper 👉 www.nature.com/articles/s41...
Isabela Corina Fortunato, PhD
I'm very happy to share my first article as a corresponding author published in @natmethods.nature.com !! 😍
Some groups (like us) have developed complex 3DTFM methods in the last 15 years.
BUT its usage in studies that help better understand disease or development has been almost non-existent.
Looking for #MaterialStiffness of #BasementMembrane across tissues?
Excellent literature resource here😆👇
The basement membrane as a structured surface – role in vascular health and disease
@claireleclech.bsky.social @jcellsci.bsky.social 2020
journals.biologists.com/jcs/article/...
The role of MicroRNAs in #MesenchymalStemCell differentiation into vascular #SmoothMuscleCell
miR-1/-133/-206
miR-143/-145
miR-221/-222-5p
miR-24
miR-181
miR-503
#CellDiv 2025
celldiv.biomedcentral.com/articles/10....
Might be an interesting review on that topic !
www.cell.com/trends/cell-...
Happy to share that my PhD has finally taken the shape of a paper! ✨
Huge thanks to all authors, especially @davidbrueckner.bsky.social & @ehannezo.bsky.social for leading the modeling and @raimonsunyer.bsky.social & @xaviertrepat.bsky.social for their invaluable supervision.
🧵👇
Stoked to announce that I received a poster award! 🔥😍
Many thanks to the #25EngLife organizers for the amazing meeting!
How do cells navigate up gradients of adhesive proteins?
🤔
Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood
We show that passive friction directs cells & explains complex trajectories on gradients
👉 www.nature.com/articles/s41...
Isabela Corina Fortunato, PhD
Jorge Barrasa Fano
Haptotaxis was traditionally seen as migration up protein gradients. It is now shown that cells can also oscillate or migrate down the gradient.
1/7: New paper alert! Excited to share our co-first author paper on Micro Immune Response On-chip (MIRO) a model that recreates the tumour-stroma interface for immunotherapy testing! @oriolmb.bsky.social and I wrote this thread to break it down for you. 👇🧵
Read more: www.nature.com/articles/s41...
Video
Hao Yin
Hao Yin
How do cells navigate up gradients of adhesive proteins?
🤔
Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood
We show that passive friction directs cells & explains complex trajectories on gradients
👉 www.nature.com/articles/s41...
Claire Dessalles
Video
Modelling the tumour immune microenvironment in vitro is a valuable tool to test immunotherapy efficiency but capturing its complexity is challenging. Here authors present a fully humanised in vitro p...
My postdoc work with @pcusachs.bsky.social is finally out! We find that fibrillar adhesions play an important role regulating the timescales of nuclear mechanotransduction. You can read all about it here : www.nature.com/articles/s41563-026-02590-x
Huge thanks to everyone involved!!
Steffen Grosser
David Brückner
David Brückner
Nuclear deformation and mechano-signalling are regulated by the coupling of vimentin cytoskeleton to the extracellular matrix through fibrillar adhesions, modulating the timescale of mechanotransducti...
Endothelial cells (ENCs) and epithelial cells (EPCs) form monolayers whose barrier
function is critical for the maintenance of physiological processes and extremely
sensitive to mechanical cues. Compu...
MicroRNAs (miRNAs) are small, noncoding RNA molecules that play a vital role in regulating gene expression, especially in the differentiation of mesenchymal stem cells (MSCs) into vascular smooth musc...
