Department of Molecular Genetics of Ageing, Max Planck Institute for Biology of Ageing
https://www.age.mpg.de/antebi/research
Antebi Lab
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We recently said goodbye to our wonderful PhD-student-turned-postdoc Klara. From C. elegans, mTOR and steroid metabolism to gardening and other new adventures. Your resilience is exemplary and your spirit contagious. We will miss you! 🪱🌿🌼 #Celegans #mTOR #goodbye
Last week we said goodbye to one of the founding members of our lab. Birgit joined the lab as a postdoc @molgen.mpg.de & rejoined when the lab moved to the @mpiage.bsky.social. She did incredible science, served as our lab manager & trained generations of junior scientists. You will be missed!
🚨Publication @micropub7n.bsky.social www.micropublication.org/journals/bio... PoC study by Y. Park: deconvolving the C. elegans proteome to organ- & tissue-level ageing trajectories expands the use of single-worm proteomics data as a powerful tool to study dynamic cellular changes during ageing.
2/4 In this study, we investigate fundamental questions about ribosome biology and ageing. While ribosomes are essential to life, how their assembly and coordination change with age, and how that contributes to ageing, remains poorly understood.
Our tiny market of longevity dreams—lab merch, publications, Flammkillifish and ‘rejuvenation’ tonics—won🥈in the annual window decoration contest!🥇to the @inahuppertz.bsky.social and Scheiblich labs chasing the Grinch for their data. Backups, people! 💾 #LabLife #AgingResearch #FestiveScience
1/4 Our preprint “Modulation of the RNase P/MRP complex and mitochondrial ribosome enhances cytosolic ribosome coordination and sustains longevity” is now live @biorxivpreprint.bsky.social 📄 #agingbiology #ribosome 👉https://www.biorxiv.org/content/10.64898/2026.02.23.707525v1
Today we said farewell to our PhD student turned postdoc Eugene Ballhysa. The energy in his conversations matched his enthusiasm for science🔬🐟We’ll miss you—and we wish you all the best for the road ahead!
3/4 Using C. elegans, we find that loss of the nucleolar regulator, ncl-1/TRIM2-3, disrupts ribosomal balance, leading to proteostasis defects and premature aging. Ribosomal biogenesis becomes uncoordinated, causing imbalanced ribosomal components and translational dysfunction.
🥳🎓Congratulations to Maja on an outstanding master’s thesis defense. Your rigor, perseverance, and dedication are exemplary. Excited to see what comes next.🌟 #GradLife #MastersDefense
4/4 Perturbing either the mitochondrial ribosome or the RNase P/MRP complex restores ribosomal balance & extends lifespan, suggesting that improving ribosome coordination, rather than reducing overall biogenesis, is a promising avenue to support cellular health in ageing.
