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Focused on innate immune mechanisms governing pathogenesis of disease and on NK-cell based therapies for disease. Opinions expressed are Dr. Waggoner's alone and not on behalf of lab staff or employer.
Waggoner Lab
Essential crosstalk between sirtuins and the sex chromosomes, with SIRT7 safeguarding X-chromosome integrity and dosage balance with autosomes @nature.com @massgenbrigham.bsky.social www.nature.com/articles/s41...
1d
Waggoner Lab
SARS-CoV-2 vaccination and infection differentially shift the memory B cell pool www.science.org/doi/10.1126/...
E. coli releases vesicles that repair membrane damage and promote survival under antibiotic stress www.science.org/doi/10.1126/...
8h
Remodeling lymph node microenvironment by radiotherapy unlocks local antibody-driven B cell depletion www.science.org/doi/10.1126/...
@biorxivpreprint.bsky.social Scalable generation of pure CD103⁺ cDC1 from iDC1 cultures www.biorxiv.org/content/10.6...
8h
8h
1d
IL-27 potentiates severe fever with thrombocytopenia syndrome by disrupting hematopoiesis and amplifying inflammation www.science.org/doi/10.1126/...
Placenta metabolic clock: NAD+ depletion triggers a countdown to birth in mice @science.org www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...
Ultrasound plus tumor cues safely prime CAR-T cells on site, enabling precise, durable attacks on solid tumors www.science.org/doi/10.1126/...
An ultrasensitive blood test accurately detects residual disease after surgery and predicts recurrence and survival in HPV+ head and neck cancer www.science.org/doi/10.1126/... @harvardmed.bsky.social
Mutation-dependent responses to sleep and exercise in clonal haematopoiesis @nature.com @sinaiimmuno.bsky.social @mcalpinelab.bsky.social www.nature.com/articles/s41...
8h
Waggoner Lab
8h
8h
8h
1d
Waggoner Lab
Waggoner Lab
Waggoner Lab
Waggoner Lab
Waggoner Lab
Waggoner Lab
Waggoner Lab
Waggoner Lab
E. coli releases vesicles that repair membrane damage and promote survival under antibiotic stress.
www.science.org
SARS-CoV-2 vaccination and infection differentially shift the memory B cell pool.
Bacterial extracellular vesicles promote membrane repair and tolerance to polymyxin B
SARS-CoV-2 variant booster vaccination and infection alter the breadth of the memory B cell repertoire
www.science.org
www.science.org
NAD+ depletion triggers a countdown to birth in mice
www.science.org
The placental metabolic clock
www.science.org
IL-27 potentiates severe fever with thrombocytopenia syndrome by disrupting hematopoiesis and amplifying inflammation.
IL-27–mediated hematopoietic dysregulation exacerbates disease severity in severe fever with thrombocytopenia syndrome virus infection
An ultrasensitive blood test accurately detects residual disease after surgery and predicts recurrence and survival in HPV+ head and neck cancer.
www.science.org
Clinical validation of an HPV whole-genome sequencing assay for MRD detection in patients with HPV+ head and neck cancer treated with surgery
Ultrasound plus tumor cues safely prime CAR-T cells on site, enabling precise, durable attacks on solid tumors.
www.science.org
Ultrasound priming gated by solid tumor hallmarks to guide CAR-T therapy