Scientist at the German Cancer Reseach Center in Heidelberg. We develop genome engineering tools for functional genomics. #CRISPR #Drosophila #openscience
Fillip Port
The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes:
🖌️ Dozens more images with duplications or painting
🖨️ Hundreds of blots that all share the same background (behold slideshow below)
1/8 🚨 New preprint from the @sternberglab.bsky.social & @martinjinek.bsky.social labs! CRISPR-associated transposases (CASTs) insert large DNA cargoes at precise genomic locations — no double-strand breaks needed.
"Artificial intelligence is rapidly accelerating scientific output, but risks narrowing inquiry, weakening judgement and undermining how scientists are trained"
www.nature.com/articles/d41...
Video
How your email finds me (not). #outofoffice #dolomites
Reese Richardson
Sternberg Lab
After months of experiments, failed injections, unexpected results, and those rare moments when everything suddenly works - our manuscript is finally submitted.
Read our newest story about a journey of tiny vesicles carrying big biological messages, now in bioRxiv. www.biorxiv.org/content/10.6...
Our Bachelor student Lara has lot's of talents beyond lab work (unfortunately forgot to take a picture of the amazing cake she made).
Has anyone already claimed their money back they paid for fraudulent products?
Fantastic recruitment for our local genome engineering scene. Welcome back to Heidelberg Jonas!
Alejandro Montenegro
Fillip Port
Fillip Port
Fillip Port
Fillip Port
1/n What fraction of the human genome is essential for cells?
Excited to share our preprint that explores this question by combining an unusual CRISPR system, phage promoters, and thousands of deletion launchpads.
@sudpinglay.bsky.social @jshendure.bsky.social
www.biorxiv.org/content/10.6...
Our latest manuscript on (Harry Potter and) the effect of elevated temperature on embryonic development in flies. Even a small increase in temperature causes developmental defects, indicating problems in the face of global warming! www.nature.com/articles/s41...
Steffen Scholpp
Kale et al. show that nuclear divisions are defective at elevated temperature, leading to gastrulation defects and embryo lethality. Their work finds that F-actin – microtubule interactions during mit...
Artificial intelligence is rapidly accelerating scientific output, but risks narrowing inquiry, weakening judgement and undermining how scientists are trained.
@johanduchene.bsky.social @sholtodavid.bsky.social
Spent the last hour looking, found ten more apparently manipulated Western blots in Thermo Fisher's antibody verification data (across eight different catalogued products). Thread below.
www.thermofisher.com/antibody/pro...
22/n On a personal note, I’ll soon start an independent research group in the Genome Biology Unit at EMBL Heidelberg. If you enjoy this type of work and want to engineer genomes at the largest scale, please reach out!
jonas-koeppel.github.io/koeppellab/
www.embl.org/groups/koepp...
Reese Richardson
Genome engineering research led by Jonas Koeppel, developing scalable technologies to design structural variants and study mammalian genome function.
