Cool. Shortsighted evolution of a bug that is maladapted in the human context, but gains ability to persist via loss of function mutations leading it to become (worryingly) more tuberculous-like. Lovely to see. BIG unanswered Q: what is Pa's natural habitat? Money on some small eukaryote 🎰
Paul Rainey
Sorry, incorrect:
"hostile conditions within the CF lung drive the acquisition and accumulation of adaptive mutations in the bacterial genome. These genetic modifications often impair the efficiency of DNA repair mechanisms, leading to a hypermutable phenotype."
Selection doesn't favor mutators
