Congratulations to Cole Sitron et al. from Ulrich Hartl's group @mpibiochem.bsky.social on this beautiful study exploring the interaction of α-synuclein aggregates with the ESCRT-III complex, now out in @cp-molcell.bsky.social - it was a pleasure to contribute to the project.
Irina Dudanova
Online Now: α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation Online now:
dlvr.it
Neurodegeneration-associated aggregates, such as α-synuclein inclusions in Parkinson’s disease, often contain ESCRT-III proteins. Sitron et al. reveal how α-synuclein aggregates bind ESCRT-III proteins, immobilizing them and triggering their “collateral degradation.” This cascade functionally depletes ESCRT-III to initiate a toxic feedback loop.
