Antonio J. Osuna Mascaró, Goffin Lab, Vienna, Austria
PhD^2 and Ninja Biologist.
Animal Behavior and Comparative Cognition.
Human perch for cockatoos.
Also here: twitter.com/BioTay
More about me here: https://osunamascaro.weebly.com/
Tay (Antonio J. Osuna Mascaró)
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6/8 This time, it was 3g. Despite years of deterioration (still evident), she was much more verbal and expressive. She was also more agile walking and more emotionally responsive
This time, she did seem to experience psychedelic effects, and reported feeling as if she were surfing with her son
8/8 Although the authors did not perform neuroimaging or use biomarkers, their hypothesis is that psilocybin may have enabled a form of functional reintegration, at least temporarily. They followed the case for a month, so we do not know how long the improvements lasted after the second session.
7/8 Of course, this is only a single case, and causality is far from demonstrated. It is also important to emphasize that psilocybin did not reverse Alzheimer’s disease. More likely, it may have allowed other neural circuits to temporarily take over functions that had been impaired by the disease.
5/8 As if that were not enough, she also began showing a sense of humor and reciprocal smiling. In short, after more than 5 years of being unable to communicate, express emotions, control urination, and so on, she recovered many of these abilities.
One month later, she was given a second session.
2/8 The woman had a 10-year history of Alzheimer’s disease (severe over the last 5). She had almost completely lost speech, communicating mostly in monosyllables. She needed help to move, had lost facial expressivity, suffered from urinary incontinence, and remained in a near-constant drowsy state.
Tay (Antonio J. Osuna Mascaró)
4/8 On day 1, she showed recognition of her relatives. Between days 2 and 3, she began walking and dressing by herself, and she also regained urinary continence. By days 6 and 7, she began showing contextual and episodic memory, while also maintaining eye contact.
3/8 Immediately after taking the mushrooms, the patient did not seem to go through a typical psychedelic experience. Instead, she entered something like a deep sleep. She woke up 19h later
When she woke up, she was no longer communicating in monosyllables. She spoke for four hours about her life.
1/8 Psilocybin and Alzheimer’s
A clinical case of a woman in her 80s with advanced Alzheimer’s disease who was given 5 g (a so-called “heroic dose”) of Psilocybe cubensis mushrooms, Enigma strain, and surprisingly recovered many of her functions.
(paper) www.frontiersin.org/journals/neu...
