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New “discrete state” model of hematopoiesis published in Nature Immunology. rdcu.be/eL8oO We propose a hierarchical model of hematopoiesis where stable “discrete states” serve as key regulatory nodes.
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Nature Immunology - Grimes and colleagues integrate multiomic features to create a framework that allows the isolation of discrete cell states across hematopoiesis and exploit the underlying gene...
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A unified multimodal single-cell framework reveals a discrete state model of hematopoiesis in mice
Lee Grimes Lab