I'm stoked to have this long-term and highly collaborative effort out in the wild. We present an experimental evolution system to quantitatively study the rapid evolutionary dynamics of B-cell affinity maturation. These evolutionary mechanisms underpin antibody responses and immune memory formation.
This started in 2019 as daydreamy PhD student musings with Tatsuya Araki. We're as excited as ever about germinal centers as a platform for experimental evolution.
Many thanks to PIs @victora.bsky.social @matsen.bsky.social, co-1st authors Ashni Vora and Tatsuya, and many other key collaborators!
Read our latest preprint. A window into GC clonal evolution upon boost.
Hi, we are looking for two motivated postdocs to join our group!
job-boards.greenhouse.io/chanzuckerbe...
job-boards.greenhouse.io/chanzuckerbe...
One more trick pulled off by antibody-mediated feedback
www.cell.com/immunity/ful...
Happy #DayofImmunology! Congrats @ramadhenni.bsky.social & Alexandra Carey Hoppé it's out (finally!) @cp-cell.bsky.social! Incredibly grateful to co-leads @mlmunier.bsky.social, Vanessa Venturi & Tony Kelleher & all brilliant folks @garvaninstitute.bsky.social & Kirby Inst. for fantastic collab! 🧵
Antibody affinity maturation results from a somatic evolutionary process that takes
place in the germinal center. A “parallel replay” experiment on germinal center B
cells reveals the evolutionary for...
I am excited to share that our work, in which we have dissected the signals driven by the nucleoside-modified mRNA and LNP components of mRNA vaccines that regulate germinal center (GC) responses, is now published in Cell! www.cell.com/cell/fulltex...
Wanted to highlight our latest preprint--a huge effort by multiple people and labs, but led primarily by @wsdewitt.github.io, Tatsuya Araki, and Ashni Vora, in a very close wet-dry collaboration with @matsen.bsky.social’s lab at the Hutch
www.biorxiv.org/content/10.1...
Check out our latest preprint on the effects of antibody-mediated feedback on ongoing germinal center reactions, led by Alex Barbulescu and @janabilanovic.bsky.social
www.biorxiv.org/content/10.1...
Roham Parsa
Happy to share our latest preprint on the clonal dynamics of GC “refueling.” We asked what happens at the clonal level after the simple (and ubiquitous) step of delivering a second vaccine dose during an ongoing GC response.
www.biorxiv.org/content/10.6...
Happy to share our latest preprint on the clonal dynamics of GC “refueling.” We asked what happens at the clonal level after the simple (and ubiquitous) step of delivering a second vaccine dose during an ongoing GC response.
www.biorxiv.org/content/10.6...
IMAGE Lab
Gabriel Victora
Gabriel Victora
Gabriel Victora
Vaccines generate long-lived plasma cells and memory B cells (Bmems) that may re-enter secondary germinal centers (GCs) to further mutate their B cell…
Antibodies generated by prior immune responses regulate B cell responses upon recall
immunization. Barbulescu et al. examine whether antibodies produced by an ongoing
immune response influence the out...
www.cell.com
www.biorxiv.org
www.biorxiv.org
Michela Locci
Gabriel Victora
Gabriel Victora
Wanted to highlight our latest preprint--a huge effort by multiple people and labs, but led primarily by @wsdewitt.github.io, Tatsuya Araki, and Ashni Vora, in a very close wet-dry collaboration with @matsen.bsky.social’s lab at the Hutch
www.biorxiv.org/content/10.1...
Serum antibodies from prior immune responses regulate B cell activation and germinal center (GC) access upon recall immunization. However, how antibodies produced by an ongoing immune response influen...
www.biorxiv.org
Darwinian evolution of immunoglobulin genes within germinal centers (GC) underlies the progressive increase in antibody affinity following antigen exposure. Whereas the mechanics of how competition be...
This study dissects the individual contributions of the different components of mRNA
vaccines to immune responses. Nucleoside-modified mRNA promotes the production of
type I interferons that act on de...
Darwinian evolution of immunoglobulin genes within germinal centers (GC) underlies the progressive increase in antibody affinity following antigen exposure. Whereas the mechanics of how competition be...
