Molecular biology on Pluribus. Rate their cloning protocol.
Lipid imaging on the cover of @nature.com! Great times for lipid cell biology indeed. And a fantastic recognition of all the hard work by the team, especially Juan M. Iglesias-Artola and Kristin Böhlig (who made the cover). Link to article: www.nature.com/articles/s41...
Happy to have contributed to this awesome finding! @slaterc.bsky.social and @thegarrettlab.bsky.social identify a mechanism by which acetoacetate drives anti-tumor immunity in the gut.
Eddie Rashan
Eddie Rashan
André Nadler
Check out the latest pre-print from the lab!
Led by our brilliant postdoc @slaterc.bsky.social
Thanks to all co-authors and collaborators. @jentekle.bsky.social @edreesrashan.bsky.social @mvhlab.bsky.social
Awesome representation from @uwmadscience.bsky.social at the @asbmb.bsky.social #ASBMB2026 meeting in DC! #ScienceServesUsAll
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
Excited to share my postdoc work @olzmannlab.bsky.social! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control!
shorturl.at/B5XYD
Our work detailing the metabolic roles of serum for cancer cell proliferation is now out at JBC, @asbmbjournals.bsky.social!
Congrats to Oliver and Eric and many thanks to the editor and reviewers for a thoughtful and efficient review process.
See here:
www.sciencedirect.com/science/arti...
U.S. President Donald Trump has fired all 24 members of the National Science Board, the body that oversees the National Science Foundation. https://scim.ag/4cxQWhl
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
Check out our Spotlight in Molecular Cell on @lydiafinley.bsky.social's lab recent work on Aconitase 2 and its protective role against impaired cell fitness and ISR activation due to mitochondrial citrate accumulation authors.elsevier.com/c/1n3Nn3vVUP...
The Garrett Lab
James Olzmann
Dismissal of the National Science Board is widely seen as latest move to erase NSF’s independence
Excited to share a preprint from my postdoc @theGarrettLab- now on bioRxiv!
Oral acetoacetate (AcAc) suppresses tumor growth by expanding and activating MAIT cells… and the mechanism was a surprise 🧵👇 (1/10)
www.biorxiv.org/content/10.1...
Fetal bovine serum (FBS) is an undefined additive that is ubiquitous to mammalian cell culture media and whose functional contributions to promoting c…
Excited to share a preprint from my postdoc @theGarrettLab- now on bioRxiv!
Oral acetoacetate (AcAc) suppresses tumor growth by expanding and activating MAIT cells… and the mechanism was a surprise 🧵👇 (1/10)
www.biorxiv.org/content/10.1...
Excited to share a recent preprint by Oliver Newsom, where we evaluate the functional contributions of serum for cancer cell proliferation. Inside:
A broadly applicable serum-free media,
Quantitative lipid uptake characterization,
Evidence lipid scavenging > synthesis for cancer cell proliferation.
Slater Clay
Slater Clay
Lucas Sullivan
www.biorxiv.org
Colorectal cancer (CRC) is a leading cause of cancer mortality and additional preventative, and therapeutic strategies are urgently needed. Ketogenic diets have mixed effects on tumorigenesis and comp...
Colorectal cancer (CRC) is a leading cause of cancer mortality and additional preventative, and therapeutic strategies are urgently needed. Ketogenic diets have mixed effects on tumorigenesis and comp...
Defined media reveals the essential role of lipid scavenging to support cancer cell proliferation https://www.biorxiv.org/content/10.1101/2025.02.12.637975v1
