We saw that when myelin sheaths are damaged, they are not always necessarily lost, using live imaging to watch the process happening in real time! Also very much enjoyed reading the perspective by Kamsi Nwangwu and Michelle Monje: www.science.org/doi/10.1126/...
Congratulations all!
I am delighted to see this work published. A big thanks to everyone, particularly the excellent supervision of @lyons-lab.bsky.social, the work of co-first author @juliavdkorput.bsky.social and wonderful collaborators in Amsterdam and Oregon.
www.science.org/doi/10.1126/...
Our latest preprint, led by @lizihegarty.bsky.social & aided by @erinwatson.bsky.social shows that fixation time matters when it comes to visualising #macrophages in #salivarygland & other epithelia.We find 1hr allows detection of mac subsets while preserving architecture. With @bainlab.bsky.social
Colonic macrophage heterogeneity revealed by CD11c and CD163 www.mucosalimmunology.org/article/S193...
Myelin damage is a hallmark of several neurological disorders, but how it occurs remains to be fully understood. In this study, we found that early damage in zebrafish and rodent demyelination models ...
How does the brain repair myelin after injury?
We mapped the full cellular choreography of white matter repair using snRNA-seq + Slide-seqv2, uncovering a type I interferon-driven glial program that recruits lymphocytes to promote remyelination.
www.biorxiv.org/content/10.1...
Details below 👇
Mucosal Immunology
Elaine Emmerson
Mike Dolan
Fixation matters: duration in fixative prior to immunofluorescent analysis directly impacts macrophage visualisation in epithelial tissues https://www.biorxiv.org/content/10.64898/2026.02.13.705745v1
