The final version of our new paper is out now - and open access @acs.org Central Science!!
Such a fun collaboration!
pubs.acs.org/doi/10.1021/...
Combining bioorthogonal protecting groups with localized catalysts that can unmask them is a powerful approach to spatially and temporally modulate molecular activity. Enzymes are appealing catalysts ...
Congratulations @genlichem.bsky.social and Xiao! Very clever probe design.
Congratulations Pete, Zach, and team!
Bryan Dickinson
Check out our review on DNA-scaffolded catalysis! This link provides free full text access until the end of 2025: authors.elsevier.com/a/1m43W9CpcY.... Big thanks to co-authors @edwardpimentel.bsky.social , Ashley Ogorek, @ethan-hartman-125.bsky.social , and Caleb Cox
Excited to share a new pre-print on a joint study between my group and @chembiobryan.bsky.social‬! Directed Evolution of Enzymes for Bioorthogonal Chemistry Using Acid Chloride Proximity Labeling. chemrxiv.org/engage/chemr...
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Jeff Martell
Jeff Martell
Combining bioorthogonal protecting groups with localized catalysts that can unmask them is a powerful approach to spatially and temporally modulate molecular activity. Enzymes are appealing catalysts ...
My work assessing the effect of preorganization on dihydrazide activity is out in @jacs.acspublications.org. We find that dihydrazides with flexible tethers can replicate much of the catalytic activity of complex dihydrazides with preorganized foldamer scaffolds. #Chemsky
doi.org/10.1021/jacs...
Jeff Martell
Jeff Martell
Philip
doi.org
We previously reported that molecules containing two cyclic hydrazide units connected by a polymethylene linker could catalyze aldol condensations via a bifunctional mechanism. One hydrazide apparentl...
In @science.org this week @zachwickens.bsky.social and collaborators find a way to do Z-selective elimination using thianthrenium chemistry in a versatile route to Z olefins.
chemsky 🧪
www.science.org/doi/10.1126/...
Happy to share our latest in @jacs.acspublications.org led by Xiao and @genlichem.bsky.social on a new activity-based sensing probe for Cu(I) using a fast alkyne-directed cleavage reaction to discover Mn-sensitized #cuproptosis as a novel type of metal-metal crosstalk! pubs.acs.org/doi/abs/10.1...
Copper is an essential element for sustaining life. However, disruptions in copper homeostasis underpin disease, as illustrated by cuproptosis, an emerging form of cell death resulting from aberrant a...
pubs.acs.org
Jake Yeston
Chris Chang
The stereoselective functionalization of C–H bonds represents a central challenge in modern organic synthesis. Despite decades of innovation in C–H activation chemistry, methods for Z-selective functi...
