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Inhibition of ATR and PKMYT1 induces synthetic lethality in RB1-deficient #BreastCancer. Important implications for pts resistant to CDK4/6 inhibitors. @mdanderson.bsky.social #EndCancer www.science.org/doi/10.1126/...
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ATR/PKMYT1 coinhibition induces synthetic lethality in Rb1-deficient breast cancers, supporting biomarker-guided therapy.
www.science.org
Rb1 deficiency induces synthetic lethality with ATR and PKMYT1 coinhibition in breast cancer cell lines and patient-derived xenografts
Albert Koong