Glycobiology | Chemical Biology | Drug Development
Prof @ Walter and Eliza Hall Institute, Melbourne, Australia
Ethan Goddard-Borger
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How do sperm and egg fuse? Surprisingly, we still don’t fully know…
Our field has uncovered many pieces of the fertilization puzzle, but not how they fit together.
We identify ✨ SPARK ✨ - a conserved sperm complex that couples sperm-egg binding to fusion.
tinyurl.com/34cm4xat
Read on! 🧵👇
Without immediate government support, 10 of Victoria's 14 medical research institutes will be forced to close within 5 years. This would be a devastating outcome for a sector which has contributed greatly to the health and economic prosperity of this country www.theaustralian.com.au/health/ten-v...
Video
www.theaustralian.com.au
WEHI researchers have helped to engineer an antibody that can clear otherwise lethal multidrug‑resistant Acinetobacter baumannii infections in mice by homing in on the bacterial sugar pseudaminic acid.
Brilliant findings, published in Nature Chemical Biology
www.wehi.edu.au/news/sugar-m...
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Victoria Deneke
Dr Monique Ryan
Thank you @endpts.com for sharing the story about Grace Science, so close to bringing gene therapy to patients with NGly1 disease, hoping for some regulatory flexibility.
endpoints.news/grace-scienc...
WEHI (The Walter and Eliza Hall Institute of Medical Research)
Check out our latest paper on the ubiquitination of glycogen in cells and tissues! Congratulations to Marco Jochem (@marcojochem.bsky.social) and Simon Cobbold for leading this study and to collaborators @craigagoodman1.bsky.social, @pgregorevic.bsky.social, Kai Hofmann and Thomas Hermanns.
Grace Science CEO Matt Wilsey says FDA demands could kill its gene therapy for the rare and fatal NGLY1 deficiency by September without new funding or a regulatory break.
"We identified 13 genome-wide significant loci associated with SARS-CoV-2 infection. The strongest signal was a single nucleotide polymorphism in an intron of ST6GAL1 (...) connected to three other associated loci (harboring MUC1, MUC5AC and MUC16)" #glycotime 🧪
www.nature.com/articles/s41...
We integrated experimental and computational approaches to generate a systems-level view of a key post-translational modification, O-GlcNAc. In vivo studies across tissues reveal shared and tissue-specific functions. Congrats to Matt, John, Yao, and the whole team! #NOTISEme bit.ly/3ZgCOBM
Interested in non-proteinaceous ubiquitination, induced proximity or glycogen? Then you should have a look at our newest article, “Ubiquitination of glycogen and metabolites in cells and tissues”, just published in Nature: www.nature.com/articles/s41...
Carolyn Bertozzi
Another postdoc position for my lab is now open. This one is for a biochemist/cell biologist who really likes mitochondria and ubiquitin. If this is you, please apply here: www.seek.com.au/job/91277535
Congratulations to the teams at Palleon and Henlius, first patients dosed with B7H3-targeted sialidase immune therapy for ovarian cancer. Great partnership around glycan editing, an exciting new approach for immune modulation #glycotime
www.businesswire.com/news/home/20...
Komander Lab
Interested in non-proteinaceous ubiquitination, induced proximity or glycogen? Then you should have a look at our newest article, “Ubiquitination of glycogen and metabolites in cells and tissues”, just published in Nature: www.nature.com/articles/s41...
Elisa Fadda
An excellent opportunity is available for a Research Officer / Senior Research Officer to join the Callegari Lab at WEHI.
Genome-wide analyses identify 13 loci associated with susceptibility to infection with SARS-CoV-2 Omicron variants, including variation in ST6GAL1, previously associated with influenza susceptibility,...
Functional studies of O-GlcNAcylation have often focused on individual modifications. Now, a systems-level approach has identified simultaneous O-GlcNAcylation events that coordinate cellular activiti...
