Uncovering the beauty of embryonic development with functional RNA biology tools. | TT Prof at @ Carl Zeiss Center for Synthetic Genomics & KIT | http://modiclab.org/
Miha Modic
Beautiful mechanistic story, how QKI by bridging intronic motifs with U6 snRNA ensures inclusion of weak 5’ splice sites that are essential for building sarcomeres. Congrats @kurianlab.bsky.social and @evannostrandlab.bsky.social labs & all involved.
Miha Modic
New Tuesday (Oct 28) in Heidelberg and online: kick off event of the Center for Synthetic Genomics: program and link to zoom: www.syn-gen.de/kick-off
Thrilled to co-advertise this postdoc or PhD position with @erhardtlab.bsky.social!
Join us, if RNP assembly on centromeres, RNA modifications, & bioinformatics are your thing.
More info also on modiclab.org.
Exited to see SPIDR finally coming out! Congrats to Marko and the team on opening the next multiplexing RNA frontier 💥
Explore RNA's role in epigenetics, DNA repair, transcription & genome organisation - directly with leaders from academia & industry at #GenReg26!
Remaining talks to be filled from submissions - register & submit by 04 Sep 2025 to join us in Mexico.
Speakers, details & registration➡️ bit.ly/46JQbze
Sylvia Erhardt
I’m a bit late to the game here, but wanted to highlight this very clever technique from @paraspeckle.bsky.social’s group! Congrats to all authors!!
We are hiring! "Researcher in DNA-Based Information Processing Systems" (PhD or postdoc level). Co-supervision by Prof. Ralf Reussner (KIT computer science) and myself (biological systems). Combination of experiments and computational work. Please Apply / Repost!
www.pse.kit.edu/english/karr...
New paper from the Trcek lab, with Siran Tian as the lead author - congratulations Siran!: www.nature.com/articles/s41...
Miha Modic
Fusion Conferences
A day late but STILL IMPORTANT
Dave Shechner
Trcek Lab
Dave Shechner
Lennart Hilbert
🧪 Open PhD or Postdoc position 🧪
The project is in collaboration with my new collegue Miha Modic. If you are interesed in RNA modification, centromeres and bioinformatics this is for you!
Miha has more positions to fill, infos on his linkedin: linkedin.com/in/miha-modic-9aa8a752.
Sylvia Erhardt
Woohoo! So psyched to see this awesome work from the Jovanovic lab out in the world! Congrats to all the authors on this tour-de-force!
www.cell.com/cell/fulltex...
Dave Shechner
New method drop:
HCR-Proxy, a modular proximity labelling approach to profile local proteome composition around RNA at nanoscale, subcompartmental resolution. Thereby we resolved nested nucleolar layers and uncovered the grammar of spatial protein partitioning.
www.biorxiv.org/content/10.1...
Miha Modic
SPIDR, a massively multiplexed method that simultaneously maps dozens of RNA-binding
proteins to their RNA targets at single-nucleotide resolution, uncovers new RNA-protein
interactions and provides c...
Tian et al. show that RNA folding limits extensive base pairing among mRNAs in Drosophila germ granules. Instead, mRNAs interact via scattered bases exposed on the surface of folded RNAs, which may pr...
Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis.
www.biorxiv.org/content/10.1...
Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.
During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...
