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OpenAccess journal dedicated to high quality research at the interface between clinical & basic science. Tweets from journal editors

EMBO Molecular Medicine

Online today 👉 Harnessing the #glycolysis #TCAcycle axis to boost host defense against #NeonatalInfection 🗞️ doi.org/10.1038/s44321-026-00463-z By Z. Wu, O. Bæk, D. Nguyen & colleagues at University of Copenhagen N&V by T. Vanderhaeghen, C. Libert & J. Vandewalle doi.org/10.1038/s44321-026-00462-0

🫁 #NETosis associates with human #tuberculosis lung tissue destruction and disease pathogenesis ➡️ doi.org/10.1038/s44321-026-00435-3 By K. Fisher, M. Marakalala & colleagues at @ahri-news.bsky.social and Stellenbosch University

Preterm infants are highly susceptible to infections that can lead to sepsis, yet therapies beyond antibiotics are limited. Nutrition and host energy metabolism are known as immune modulators, but how they interact to mediate newborn host infection defense remains poorly understood. Here, we identify tricarboxylic acid (TCA) cycle metabolites as key modulators of early life infection outcomes. First, in a birth cohort of 700 children, elevated plasma TCA metabolite levels were associated with reduced infection burdens and systemic inflammation. Next, in a piglet neonatal sepsis model, sustained hepatic TCA cycle activity was associated with survival. These led us to explore clinically relevant nutritional strategies boosting TCA cycle activity. Substituting glucose in parenteral nutrition for galactose or glucogenic amino acids improved both pathogen clearance and preserved glucose homeostasis and prevented lethal sepsis. Mechanistically, these interventions promoted hepatic metabolic rewiring from glycolysis toward TCA-cycle-based oxidative phosphorylation, while mitigating excessive inflammation and organ injury. Our findings establish a clear connection between systemic energy metabolism and neonatal infection defense, suggesting clinically relevant strategies to improve outcomes in vulnerable newborns.

EMBO Molecular Medicine

Soluble #TREM2 engages cell-surface nucleolin to drive #VascularPermeability and malignant ascites in #OvarianCancer 🗞️ doi.org/10.1038/s44321-026-00452-2 by Q. Li, X. Huang, S. Guo, B. Xie, H. He & colleagues at University of Macau & The Fifth Affiliated Hospital of Sun Yat-sen University

Our editor Lise Roth is attending #TumorMetabolism : Diet, #Microbiome & Beyond, starting today in Killarney with @keystoneSymposia.bsky.social Reach out and talk to her about your research! keysym.us/KSTumorMetab26 #KSTumorMetab26

Mitochondrial activity promotes #neutrophil degranulation and endothelial dysfunction in #SystemicInfections By P. Zakrzewski, B. Amulic & colleagues @bristoluni.bsky.social 👉 doi.org/10.1038/s44321-026-00453-1

NeoCircle: pre- and post-operative #ctDNA dynamics predicts survival in neoadjuvant-treated early #BreastCancer By A. George, @laosaal.bsky.social & colleagues at @lund-university.bsky.social 🗞️ doi.org/10.1038/s44321-026-00447-z Press release: www.lunduniversity.lu.se/article/bloo...

WEE1 kinase inhibition to overcome #acquired #resistance to targeted therapies in #ColorectalCancer By K. Buzo, S. Arena & colleagues at Candiolo Cancer Institute & University of Torino 👉 doi.org/10.1038/s443...

#Adipocytes influence #choroidal #neovascularization via PRDM16 🗞️ doi.org/10.1038/s44321-026-00441-5 by A. Wilson, S. Crespo-Garcia, P. Sapieha & colleagues @umontreal-en.bsky.social

Functional screening of TCR-like antibodies using STAR-T cell library for #cancer #immunotherapy By Yi Li, Xin Lin & colleagues at Tsinghua University ➡️ doi.org/10.1038/s44321-026-00455-z

EMBO Molecular Medicine

Join us at the Keystone Symposia on Tumor Metabolism: New Frontiers in Diet, Microbiome and Beyond, June 2026, in Killarney, with field leaders!

EMBO Molecular Medicine

Fantastic to see this work published, congratulations to all co-authors! It further validates the value of structural variants (SVs) as biomarkers for cancer liquid biopsy, as implemented in SAGA Diagnostics' Pathlight MRD test. #ctDNA #MRD #LiquidBiopsy #PrecisionMedicine #BrCa #BreastCancer

EMBO Molecular Medicine