Active Nematics & Synthetic Morphogenesis
Former @rouxlab.bsky.social @xaviertrepat.bsky.social
Pau Guillamat
Loading...
Our latest work on shape-programmable tissues is out in @science.org. By positioning topological defects in cellular nematics, we encode frustrated 2D force fields that relax into predictable 3D shapes. Collaboration with Marino Arroyo’s lab, led by @pauguillamat.bsky.social at @ibecbarcelona.eu.
Video
Xavier Trepat
Since #durotaxis was described >25 years ago, most studies report cells migrating from soft → stiff
New work from my team at @ub.edu (in collaboration with D. Odde's lab) suggests we may have been missing the point all along...
🔥 Check out our new preprint here 👇
www.biorxiv.org/content/10.6...
Development builds... But it also breaks!
Planarians split to reproduce. Hydra tears open a mouth. Embryos fracture to make cavities.
Failure? No. Fracture is essential to development.
Our new review on fracture physics and its uses in development:
journals.biologists.com/dev/article/...
www.biorxiv.org
Raimon Sunyer
Summary: This Review presents mechanical fracture as a unifying morphogenetic strategy and describes how developmental systems actively exploit mechanical fracture to drive morphogenesis, reproduction...
Really excited to share our new paper in @nature.com! We uncovered how a physical instability of the cytoplasm coupled with the cell cycle drives cytoplasmic partitioning in early embryos #zebrafish #drosophila. Read more in this🧵 www.nature.com/articles/s41... 🤩
@poldresden.bsky.social @mpi-cbg.de
Our review article is now available in Annual Review of Condensed Matter Physics: “Full-Integer Topological Defects in Polar Active Matter.” @luizaangheluta.bsky.social @emmalaang.bsky.social doi.org/10.1146/annu...
From active chaos to crystallinity!
We show that chaotic active turbulence in active nematics can self-organize into a spatiotemporal crystal: a lattice of density, orientation, and vorticity that breaks both spatial and temporal symmetry.
arxiv.org/abs/2603.12079
#ActiveMatter
Just published in @science.org 🚀
By controlling how cells align, we show that living nematic tissues can be programmed to generate forces and fold into predictable 3D shapes.
A new platform for tissue engineering and the design of smart active materials!
www.science.org/doi/10.1126/...
How do epithelial cells organize uniform polar orientation during long-range collective migration?
I'm @emmalaang.bsky.social , and my research focus on collective cell behaviors. In this thread, I will take you through the concept of topology-guided polar ordering of collective cell migration
Stig Ove Bøe
Brugues Lab
Our latest with @torres-sanchez.bsky.social journals.biologists.com/dev/article-...
Breaking isn’t always a bad thing! Think of birth, seed release...
We highlight how living tissue not only tolerates fractures but actively fracture to grow, shape, reproduce, or adapt – across species and scales.
Per Sant Jordi, us deixem una rosa feta de ciència 🌹🔬
Controlant la posició dels defectes topològics en nemàtics cel·lulars, s'han programat camps de forces 2D frustrats que es relaxen en formes 3D predictibles.
Summary: This Review presents mechanical fracture as a unifying morphogenetic strategy and describes how developmental systems actively exploit mechanical fracture to drive morphogenesis, reproduction...
New preprint out! We show how cellular nematic order can be harnessed to program tissue-wide force fields and guide 3D shape transformations.
The tissue morphogenesis logic, now engineered into living, programmable materials.
www.biorxiv.org/content/10.1...
#ActiveMatter #TissueEngineering
epithelial mechanics fan club
#LivingArchitectures
We put cells and cytoskeleton filaments on the architecture of the musée d'Orsay.
www.musee-orsay.fr/fr/agenda/ev...
Scientists of the #CytoMorphoLab adapted their protocols to illustrate the questions that keep them awake at night.
-> Two shows on the 24th and 25th of January.
