Professor at Forschungszentrum Jülich and HHU Düsseldorf. Phage-host interaction, regulatory networks, metabolic engineering, SPP 2330
Julia Frunzke
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Registration opened for our International Symposium of SPP 2330! This is going to be phage-tastic meeting in Berlin!
Highlight of the second funding period!
@spp2330.bsky.social, @dfg.de
#Biofilm matrices containing filamentous phages help #Pseudomonas aeruginosa tolerate antibiotics. @abultarafder.bsky.social @tbharat-lab.bsky.social &co show that #nanobody disruption of #phage Pf4 #LiquidCrystalline droplets restores #antibiotic susceptibility @plosbiology.org 🧪 plos.io/4xkd6Mw
David Attenborough has raised awareness of the natural world and its myriad interconnections on which humans depend
go.nature.com/48RTqVz
Must read: @spp2330.bsky.social
Experienced researchers are less likely to produce ‘disruptive’ science than are those just starting their careers, finds an analysis of scientific papers published by 12.5 million researchers over 60 years
go.nature.com/3Pb1lqg
Happy to share our latest pre-print on the Druantia defense system.
We find that Type III Druantia uses a cooperative helicase-nuclease mechanism to sense and degrade replication-associated forked DNA structures.
www.biorxiv.org/content/10.6...
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Please RT:
Registration is ongoing for our International Symposium "Microbial Networking - from organelles to cross-kingdom communities" organized as highlight of the first funding period of CRC 1535 @mibinet.bsky.social
www.sfb1535.hhu.de/internationa...
@dfg.de, @hhu.de, @fz-juelich.de
Our paper is out! Hiding in plain sight among Cas12a nucleases, Cas12a3 cleaves not its RNA target but the 3′ ends of tRNA. Huge thanks to all who made this possible, especially the Beisel lab, Biao & Dirk for the structure, & @sebastianglatt.bsky.social for all things tRNA. doi.org/10.1038/s415...
Now out in @pnas.org 🥳
"DNA-intercalating antiphage molecules trigger abortive infection through mutual destruction and synergize with bacterial immunity"
--> bad timing can kill you, even as a virus.
www.pnas.org/doi/10.1073/...
@spp2330.bsky.social, @mibinet.bsky.social, @dfg.de
Exciting times for our lab- recent developments in cryoET tools and workflows now allow us apply these to study microbes in the host context. #teamtomo
www.sciencedirect.com/science/arti...
Nature - The science communicator has raised awareness of the natural world andits myriad interconnections on which humans depend.
Cas12a3 nucleases constitute a distinct clade of type V CRISPR–Cas bacterial immune systems that preferentially cleave the 3′ tails of tRNAs after recognition of target RNA to induce growth arres...
Cryo-electron tomography (cryo-ET) has revolutionized visualization of bacterial nanomachines by revealing molecular structures in situ under near-nat…
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
📢 Registration for our International Symposium on “New Concepts in Prokaryotic Virus-Host Interactions” is now open!
🗓️ 5–7 October 2026
📍 Harnack House, Berlin, Germany
➡️ Information and registration: spp2330.de/symposium-20...
With Eugene Koonin, we wrote a rather comprehensive review on the origin, evolution and organization of the #virosphere. We describe all 10 viral realms and the logic behind them, and so much more. Check it out! comptes-rendus.academie-sciences.fr/biologies/ar...
Happy to share our recent preprint:
"DNA-intercalating antiphage molecules trigger abortive infection through mutual destruction and synergize with bacterial immunity"
www.biorxiv.org/content/10.6...
@spp2330.bsky.social, @mibinet.bsky.social, @dfg.de @hhu.de @fzj.bsky.social
New Concepts in Prokaryotic Virus-Host Interaction
