Over the past 5 years, 50 structures of full-length HECT-type ligase constructs have been deposited in the PDB. What have we learned from these studies, and what key questions remain open? Check out our new review on this exciting and fast-moving field: www.jbc.org/article/S002...
Ubiquitin coordinates a complex network of cellular pathways through covalent modification
of substrates. Specificity in substrate recognition and modification choice is largely
conferred by ubiquitin...
